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Pharmaceutisch Weekblad

, Volume 4, Issue 1, pp 1–4 | Cite as

Org-NC45: a new steroidal non-depolarizing muscle relaxant

  • L. H. D. J. Booij
  • T. B. Vree
  • J. F. Crul
Review Articles
  • 31 Downloads

Abstract

Although pancuronium has fewest side effects compared to other currently used non-depolarizing muscle relaxants, it is still not the ideal relaxant. Its structural analogues have been studied to derive such an ideal relaxant. Org-Nc45 meets the requirements for such a relaxant best and is therefore extensively studied. It is more potent than pancuronium, has a shorter onset and duration of action and is free from cardiovascular side effects. Histamine release could not be demonstrated. It can be easily reversed by neostigmine, pyridostigmine or 4-aminopyridine. Interaction with antibiotics and anaesthetic drugs is not different from that of pancuronium.

Keywords

Public Health Internal Medicine Histamine Muscle Relaxant Structural Analogue 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1982

Authors and Affiliations

  • L. H. D. J. Booij
    • 1
  • T. B. Vree
    • 1
  • J. F. Crul
    • 1
  1. 1.Department of AnaesthesiologySt. Radboud hospitalNijmegenThe Netherlands

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