Production of siderophore by coagulase-negative staphylococci and its relation to virulence

  • J. A. Lindsay
  • T. V. Riley
  • B. J. Mee


The ability to produce siderophore is considered to be a virulence factor for many pathogenic bacteria. To determine if siderophore production by coagulase-negative staphylococci (CNS) was related to virulence, 40 clinical isolates of CNS cultured from peritoneal dialysis fluid were compared with 38 commensal skin isolates. Siderophore activity was detected using the chrome azurol S liquid assay. Using precursor studies,Staphylococcus epidermidis isolates were shown to be more likely to produce the siderophore staphyloferrin A. Production of staphyloferrin B amongst non-Staphylococcus epidermidis species was associated with clinical isolates rather than commensal isolates, and therefore may play a role in pathogenicity.


Internal Medicine Chrome Peritoneal Dialysis Virulence Factor Clinical Isolate 
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Copyright information

© Friedr. Vieweg & Sohn Verlagsgesellschaft mbH 1994

Authors and Affiliations

  • J. A. Lindsay
    • 1
  • T. V. Riley
    • 2
  • B. J. Mee
    • 1
  1. 1.Department of MicrobiologyUniversity of Western Australia, Queen Elizabeth II Medical CentreNedlandsAustralia
  2. 2.Department of Clinical MicrobiologySir Charles Gairdner Hospital, Queen Elizabeth II Medical CentreNedlandsAustralia

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