Digestive Diseases and Sciences

, Volume 41, Issue 12, pp 2471–2476

Intravenous cyclosporine in attacks of ulcerative colitis

Short-term and long-term responses
  • Franck Carbonnel
  • Arnaud Boruchowicz
  • Bernard Duclos
  • Jean Claude Soulé
  • Eric Lerebours
  • Marc Lémann
  • Jean Belaïche
  • Jean Frédéric Colombel
  • Jacques Cosnes
  • Jean Pierre Gendre
Intestinal Disorders, Inflammatory Bowel Disease, And Irritable Bowel Syndrome

DOI: 10.1007/BF02100145

Cite this article as:
Carbonnel, F., Boruchowicz, A., Duclos, B. et al. Digest Dis Sci (1996) 41: 2471. doi:10.1007/BF02100145

Abstract

The present study reports the results of intravenous cyclosporine in 32 patients with refractory and/or severe attacks of ulcerative colitis (UC). Twenty of 32 patients responded to intravenous cyclosporine; cyclosporine was clinically effective and improved colonic lesions. However, one colonic perforation and one postoperative death were observed in two patients with severe endoscopic colitis who had failed to reach clinical remission with high-dose corticosteroids and cyclosporine. Moreover, after a median follow-up of 190 days, only one-third of the patients avoided colectomy. No predictive factor of response to cyclosporine was identified. This study confirms that cyclosporine is effective in severe UC but suggests that its use could be associated with serious complications in patients with severe lesions who had failed to settle with corticosteroids and cyclosporine.

Key words

ulcerative colitis cyclosporine acute colitis 

Copyright information

© Plenum Publishing Corporation 1996

Authors and Affiliations

  • Franck Carbonnel
    • 1
    • 2
    • 3
    • 4
    • 5
    • 6
  • Arnaud Boruchowicz
    • 1
    • 2
    • 3
    • 4
    • 5
    • 6
  • Bernard Duclos
    • 1
    • 2
    • 3
    • 4
    • 5
    • 6
  • Jean Claude Soulé
    • 1
    • 2
    • 3
    • 4
    • 5
    • 6
  • Eric Lerebours
    • 1
    • 2
    • 3
    • 4
    • 5
    • 6
  • Marc Lémann
    • 1
    • 2
    • 3
    • 4
    • 5
    • 6
  • Jean Belaïche
    • 1
    • 2
    • 3
    • 4
    • 5
    • 6
  • Jean Frédéric Colombel
    • 1
    • 2
    • 3
    • 4
    • 5
    • 6
  • Jacques Cosnes
    • 1
    • 2
    • 3
    • 4
    • 5
    • 6
  • Jean Pierre Gendre
    • 1
    • 2
    • 3
    • 4
    • 5
    • 6
  1. 1.From the Services de Gastroentérologie of Hôpital Claude-HuriezLille
  2. 2.Hôpital de HautepierreStrasbourg
  3. 3.Hôpital Louis MourierColombes
  4. 4.Hôpital Charles NicolleRouen, Liège
  5. 5.Hôpital Saint-LouisParis
  6. 6.Service de Gastroentérologie et NutritionHôpital RothschildParisFrance

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