Journal of Molecular Evolution

, Volume 21, Issue 2, pp 199–201 | Cite as

Quantitative polyphosphate-induced “prebiotic” peptide formation in H2O by addition of certain azoles and ions

  • J. Rabinowitz
  • A. Hampaï


Aqueous solutions of 0.1 M amino acid and 0.1 M trimetaphosphate maintained at chosen pH values between 8.0 and 10.5 and at room temperature in the presence of imidazole or 1,2,4-triazole give rise after a few days to the corresponding peptides. Yields are highest when the pH is adjusted with concentrated NaOH or KOH instead of ammonia; in some cases glycine is quantitatively transformed within 10–15 days into peptides, mainly diand tripeptides.

Key words

Prebiotic condensation Aqueous solution Trimetaphosphate Amino acids Peptides Imidazole 1,2,4-Triazole Sodium Potassium Ammonium 


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Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • J. Rabinowitz
    • 1
  • A. Hampaï
    • 2
  1. 1.Center for Human Ecology and Environmental SciencesUniversity of GenevaGeneva 4Switzerland
  2. 2.Central Laboratory of Clinical ChemistryUniversity Hospital of GenevaGenevaSwitzerland

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