An RNA replisome as the ancestor of the ribosome
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The ribosome is proposed to have evolved from an earlier RNA-replisome, which synthesized RNA. Ancestral tRNA molecules originally were loaded with trinucleotide sequences and donated them to growing RNA chains. The enzymatic addition of the C-C-A trinucleotide to presentday transfer RNA molecules is a carryover from this function. The strategies of reading RNA sequences by triplet codons and of housing information genetically in special repository molecules predates the origin of protein and DNA. These latter two polymers arose together at the time when the RNA replisome was converted to a ribosome.
Key wordsRepository RNA Triplet code Origin of protein synthesis RNA replication RNA world Transfer RNA Translation
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- Benner SA, Allemann RK, Ellington AD, Ge L, Glasfeld A, Leanz GF, Krauch T, MacPherson LJ, Moroney S, Piccirilli JA (1987) Natural selection, protein engineering, and the last riboorganism: rational model building in biochemistry. In Symposia on quantitative biology, vol 52. Cold Spring Harbor Laboratories, Cold Spring Harbor NY, pp 53–63Google Scholar
- Melton DA (ed) (1988) Antisense RNA and DNA. Cold Spring Harbor Laboratories, Cold Spring Harbor NY, 149 pGoogle Scholar
- Priano C, Dramer FR, Mills DR (1987) Evolution of the RNA coliphages: the role of secondary structure during RNA replication. In Symposia on quantitative biology, vol 52. Cold Spring Harbor Laboratories, Cold Spring Harbor NY, pp 321–330Google Scholar