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Journal of Molecular Evolution

, Volume 32, Issue 1, pp 3–5 | Cite as

An RNA replisome as the ancestor of the ribosome

  • John H. Campbell
Article

Summary

The ribosome is proposed to have evolved from an earlier RNA-replisome, which synthesized RNA. Ancestral tRNA molecules originally were loaded with trinucleotide sequences and donated them to growing RNA chains. The enzymatic addition of the C-C-A trinucleotide to presentday transfer RNA molecules is a carryover from this function. The strategies of reading RNA sequences by triplet codons and of housing information genetically in special repository molecules predates the origin of protein and DNA. These latter two polymers arose together at the time when the RNA replisome was converted to a ribosome.

Key words

Repository RNA Triplet code Origin of protein synthesis RNA replication RNA world Transfer RNA Translation 

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References

  1. Altman S (1989) Ribonuclease P: an enzyme with a catalytic RNA subunit. Adv Enzymol 62:1–36PubMedGoogle Scholar
  2. Arai K-I, Low RL, Kornberg A (1981) Movement and site selection for priming by the primosome in phage phiX174 DNA. Proc Natl Acad Sci USA 78:707–711PubMedGoogle Scholar
  3. Benner SA, Allemann RK, Ellington AD, Ge L, Glasfeld A, Leanz GF, Krauch T, MacPherson LJ, Moroney S, Piccirilli JA (1987) Natural selection, protein engineering, and the last riboorganism: rational model building in biochemistry. In Symposia on quantitative biology, vol 52. Cold Spring Harbor Laboratories, Cold Spring Harbor NY, pp 53–63Google Scholar
  4. Benner SA, Ellington AD, Tauer A (1989) Modern metabolism as a palimpsest of the RNA world. Proc Natl Acad Sci USA 86:7054–7058PubMedGoogle Scholar
  5. Bloch DP (1988) Cybernetic origins of replication. Orig Life Evol Biosphere 18:87–96CrossRefGoogle Scholar
  6. Cech TR, Bass BL (1986) Biological catalysis by RNA. Annu Rev Biochem 55:599–629CrossRefPubMedGoogle Scholar
  7. Cedergren R, Grosjean H (1987) On the primacy of primordial RNA. Biosystems 20:175–180CrossRefPubMedGoogle Scholar
  8. Crick FHC (1968) The origin of the genetic code. J Mol Biol 38:367–379CrossRefPubMedGoogle Scholar
  9. Deutscher MP (1973) Synthesis and function of the-C-C-A terminus of transfer RNA. Prog Nucleic Acid Res Mol Biol 13:51–92PubMedGoogle Scholar
  10. Edwards MR (1989) A possible origin of RNA catalysis in multienzyme complexes. Orig Life Evol Biosphere 19:69–72CrossRefGoogle Scholar
  11. Gibson TJ, Lamond AI (1990) Metabolic complexity in the RNA world and implications for the origin of protein synthesis. J Mol Evol 30:7–15PubMedGoogle Scholar
  12. Green PJ, Pines O, Inouye M (1986) The role of antisense RNA in gene regulation. Annu Rev Biochem 55:569–597CrossRefPubMedGoogle Scholar
  13. Guerrier-Takada C, Altman S (1989) Specific interactions in RNA enzyme-substrate complexes. Science 246:1578–1584PubMedGoogle Scholar
  14. Lazcano A, Guerrero R, Margulis L, Oro J (1988) The evolutionary transition from RNA to DNA in early cells. J Mol Evol 27:283–290PubMedGoogle Scholar
  15. McSwiggen JA, Cech TR (1989) Stereochemistry of RNA cleavage by theTetrahymena ribozyme and evidence that the chemical step is not rate-limiting. Science 244:679–683PubMedGoogle Scholar
  16. Melton DA (ed) (1988) Antisense RNA and DNA. Cold Spring Harbor Laboratories, Cold Spring Harbor NY, 149 pGoogle Scholar
  17. Priano C, Dramer FR, Mills DR (1987) Evolution of the RNA coliphages: the role of secondary structure during RNA replication. In Symposia on quantitative biology, vol 52. Cold Spring Harbor Laboratories, Cold Spring Harbor NY, pp 321–330Google Scholar
  18. Saiki RK, Scharf S, Faloona F, Mullis KB, Horn GT, Ehrlich HA, Arnheim N (1985) Enzymatic amplification of beta-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia. Science 230:1350–1354PubMedGoogle Scholar
  19. Weiner AM (1988) Eukaryotic nuclear telomeres: molecular fossils of the RNP world? Cell 52:155–158CrossRefPubMedGoogle Scholar
  20. Weiner AM, Maizels N (1987) tRNA-like structures tag the 3′ ends of genomic RNA molecules for replication: implications for the origin of protein synthesis. Proc Natl Acad Sci USA 84:7383–7387PubMedGoogle Scholar

Copyright information

© Springer-Verlag New York Inc. 1991

Authors and Affiliations

  • John H. Campbell
    • 1
    • 2
    • 3
  1. 1.Department of Anatomy and Cell Biology, School of MedicineUniversity of CaliforniaLos AngelesUSA
  2. 2.Center for the Study of EvolutionUniversity of CaliforniaLos AngelesUSA
  3. 3.Origin of LifeUniversity of CaliforniaLos AngelesUSA

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