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Pharmaceutisch Weekblad

, Volume 7, Issue 4, pp 146–149 | Cite as

Formulation of a stable p-acetylaminohippurate infusion fluid and determination of the serum concentrations

  • L. M. L. Stolk
  • L. S. Chandi-Bakridi
  • J. C. Filedt Kok
  • M. G. Koopman
  • F. M. J. Zuyderhoudt
  • L. Arisz
Original Articles

Abstract

An infusion fluid withp-acetylaminohippurate (PACAH) was formulated and a method for analysis of PACAH in serum, urine and infusion fluid based on reversed phase HPLC was developed. No significant degradation could be observed after steam sterilization for twenty minutes at 120‡C. From the results of an investigation of the degradation rate at elevated temperatures a negligible loss of content during storage for three years at 20‡C could be predicted. Steady state serum concentrations of PACAH after constant infusion were determined.

Keywords

Public Health Internal Medicine Steady State Elevated Temperature Serum Concentration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Bohn, Scheltema & Holkema 1985

Authors and Affiliations

  • L. M. L. Stolk
    • 1
  • L. S. Chandi-Bakridi
    • 1
  • J. C. Filedt Kok
    • 1
  • M. G. Koopman
    • 2
  • F. M. J. Zuyderhoudt
    • 2
  • L. Arisz
    • 2
  1. 1.Department of PharmacyAcademic Medical CentreAZ AmsterdamThe Netherlands
  2. 2.Department of Internal MedicineAcademic Medical CentreAZ AmsterdamThe Netherlands

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