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Pharmaceutisch Weekblad

, Volume 7, Issue 4, pp 125–133 | Cite as

Predictive testing in cancer chemotherapy

II. In vitro
  • P. H. Th. J. Slee
  • A. T. van Oosterom
  • E. A. de Bruijn
Review Articles

Abstract

During the last thirty years severalin vitro techniques have been developed to predict sensitivity of individual tumours. When the results of these techniques were correlated with the clinical response in larger groups of patients, the accuracy for predicting resistance was greater than for predicting sensitivity. Amongst the culture techniques the colony-forming assays have received much attention. Research with tumour cell lines and the sound biological basis do support this preference on other techniques. Studies on these assays have come from several independent laboratories, who report comparable results. Improvement of the culture technique and more insight into thein vitro pharmacology is needed, before application on wider scale is justified. Colony-forming culture techniques have not only been propagated for individualized chemotherapy, but also for drug screening. New antitumour agents and analogues can be screened in a short time for their sensitivity in many histologic tumour types.

Keywords

Public Health Tumour Cell Internal Medicine Clinical Response Comparable Result 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Bohn, Scheltema & Holkema 1985

Authors and Affiliations

  • P. H. Th. J. Slee
    • 1
  • A. T. van Oosterom
    • 1
  • E. A. de Bruijn
    • 1
  1. 1.Department of Clinical OncologyState University of LeidenAA LeidenThe Netherlands

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