Effect of systemic gastric acid stimulation and intragastric pH changes on synchronous antral gastrin and somatostatin release in anesthetized, nonatropinized duodenal ulcer patients and controls
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The synchronous changes in antral gastrin and somatostatin release in anesthetized, nonatropinized duodenal ulcer patients and control subjects were investigated by serial intraoperative blood sampling from the right gastroepiploic vein. The mean basal antral plasma gastrin and somatostatin concentrations of the two groups did not differ significantly. The significantly greater gastric acid secretory response to systemic gastric acid stimulation (pentagastrin stimulation) in duodenal ulcer patients compared with that of control subjects was not linked to any difference in antral somatostatin release pattern. The decrease in antral plasma gastrin release was significantly lower after acid instillation and the increase was significantly higher after alkali instillation in duodenal ulcer patients compared with those of controls, indicating an abnormal gastrin response to intragastric pH changes in duodenal ulcer patients, which was again not found to be coupled to any significant difference in antral somatostatin release. The results suggest that an abnormal somatostatin-mediated inhibition of gastrin release and/or gastric acid secretion does not exist in duodenal ulcer patients.
Key wordsduodenal ulcer somatostatin gastrin
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- 2.Holst JJ, Knuhtsen S, Jensen SL, Fahrenkrug I, Larsson LI, Nielsen OV: Interrelation of nerves and hormones in stomach and pancreas. Scand J Gastroenterol 18(suppl)82:85–99, 1983Google Scholar
- 3.Lucey MR, Yamada T: Biochemistry and physiology of gastrointestinal somatostatin. Dig Dis Sci 34:55, 1989Google Scholar
- 4.Park J, Chiba T, Yamada T: Mechanisms for direct inhibition of canine gastric parietal cells by somatostatin. J Biol Chem 262:14190–14196, 1982Google Scholar
- 7.Harty RF, Maico DG, McGuigan JE: Antral release of gastrin and somatostatin in duodenal ulcer and control subjects. Gut 27:52–58, 1986Google Scholar
- 8.Nakada K, Mitsuma T, Furusawa A, Maeda Y, Jizuka A, Monise K: TRH, VIP and somatostatin in human gastric juice. Biomed Res 9(suppl):141–146, 1988Google Scholar
- 10.Tietz NW, Rinker AD, Henderson R: Gastric, pancreatic and intestinal function.In Textbook of Clinical Chemistry. NW Tietz (ed). Philadelphia, WB Saunders, 1986, pp 1455–1456.Google Scholar
- 14.Ellison EC, O'Dorisio TM, Woltering EA, Sparks J, Makhjian HB, Fromkes JJ, Carey LC: Suppression of gastrin and gastric acid secretion in the Zollinger-Ellison syndrome by long-acting somatostatin (SMS 201–995). Scand J Gastroenterol 21(suppl):206–211, 1986Google Scholar