Advertisement

Digestive Diseases and Sciences

, Volume 39, Issue 10, pp 2143–2148 | Cite as

Effect of systemic gastric acid stimulation and intragastric pH changes on synchronous antral gastrin and somatostatin release in anesthetized, nonatropinized duodenal ulcer patients and controls

  • Zafer Ferahköşe
  • Hüseyn Altinyollar
  • B. Bülent Menteş
Esophageal, Gastric, And Duodenal Disorders

Abstract

The synchronous changes in antral gastrin and somatostatin release in anesthetized, nonatropinized duodenal ulcer patients and control subjects were investigated by serial intraoperative blood sampling from the right gastroepiploic vein. The mean basal antral plasma gastrin and somatostatin concentrations of the two groups did not differ significantly. The significantly greater gastric acid secretory response to systemic gastric acid stimulation (pentagastrin stimulation) in duodenal ulcer patients compared with that of control subjects was not linked to any difference in antral somatostatin release pattern. The decrease in antral plasma gastrin release was significantly lower after acid instillation and the increase was significantly higher after alkali instillation in duodenal ulcer patients compared with those of controls, indicating an abnormal gastrin response to intragastric pH changes in duodenal ulcer patients, which was again not found to be coupled to any significant difference in antral somatostatin release. The results suggest that an abnormal somatostatin-mediated inhibition of gastrin release and/or gastric acid secretion does not exist in duodenal ulcer patients.

Key words

duodenal ulcer somatostatin gastrin 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Larsson LI: Peptide secretory pathways in gastrointestinal tract: Cytochemical contributions to regulatory physiology of the gut. Am J Physiol 239:G237-G247, 1980PubMedGoogle Scholar
  2. 2.
    Holst JJ, Knuhtsen S, Jensen SL, Fahrenkrug I, Larsson LI, Nielsen OV: Interrelation of nerves and hormones in stomach and pancreas. Scand J Gastroenterol 18(suppl)82:85–99, 1983Google Scholar
  3. 3.
    Lucey MR, Yamada T: Biochemistry and physiology of gastrointestinal somatostatin. Dig Dis Sci 34:55, 1989Google Scholar
  4. 4.
    Park J, Chiba T, Yamada T: Mechanisms for direct inhibition of canine gastric parietal cells by somatostatin. J Biol Chem 262:14190–14196, 1982Google Scholar
  5. 5.
    Park J, Chiba T, Yokotani K, Delaville J, Yamada T: Somatostatin receptors on camine fundic D-cells: Evidence for autocrine regulation of gastric somatostatin. Am J Physiol 257(suppl):G308-G312, 1989PubMedGoogle Scholar
  6. 6.
    Sumii K, Fukushima T, Hirata K, Matsumoto Y, Sanuki E, Tsumaru S, Sumioka M, Miyoshi A, Miyachi Y: Antral gastrin and somatostatin concentrations in peptic ulcer patients. Peptides 2(suppl):281–283, 1981PubMedGoogle Scholar
  7. 7.
    Harty RF, Maico DG, McGuigan JE: Antral release of gastrin and somatostatin in duodenal ulcer and control subjects. Gut 27:52–58, 1986Google Scholar
  8. 8.
    Nakada K, Mitsuma T, Furusawa A, Maeda Y, Jizuka A, Monise K: TRH, VIP and somatostatin in human gastric juice. Biomed Res 9(suppl):141–146, 1988Google Scholar
  9. 9.
    Mueller CR, Ure T, O'Dorisio TM, Barrie RJ, Woltering EA: Acute gastric pH changes alter intraluminal but not plasma peptide levels. Surgery 110:1116–1124, 1991PubMedGoogle Scholar
  10. 10.
    Tietz NW, Rinker AD, Henderson R: Gastric, pancreatic and intestinal function.In Textbook of Clinical Chemistry. NW Tietz (ed). Philadelphia, WB Saunders, 1986, pp 1455–1456.Google Scholar
  11. 11.
    Bloom SR, Mortimer CH, Thorner MO, Esser GM, Hall R, Gomez-Pan A, Roy VM, Russel ROG, Coy DH, Kastin AJ, Schally AV: Inhibition of gastrin and gastric acid secretion by growth hormone release inhibiting hormone. Lancet 2:1106–1109, 1974PubMedGoogle Scholar
  12. 12.
    Raptis S, Dollinger HC, von Berger L, Schegel W, Schroder KE, Pfeiffer EF: Effects of somatostatin on gastric secretion and gastrin release in man. Digestion 13:15–26, 1975PubMedGoogle Scholar
  13. 13.
    Loud FB, Holst JJ, Egense E, Petersen B, Christiansen J: Is somatostatin a humoral regulator of the endocrine pancreas and gastric acid secretion in man. Gut 26:445–449, 1985PubMedGoogle Scholar
  14. 14.
    Ellison EC, O'Dorisio TM, Woltering EA, Sparks J, Makhjian HB, Fromkes JJ, Carey LC: Suppression of gastrin and gastric acid secretion in the Zollinger-Ellison syndrome by long-acting somatostatin (SMS 201–995). Scand J Gastroenterol 21(suppl):206–211, 1986Google Scholar
  15. 15.
    Colturi TJ, Unger RH, Feldman M: Role of circulating somatostatin in regulation of gastric acid secretion, gastrin release and islet cell function; Studies in healthy subjects and duodenal ulcer patients. J Clin Invest 74:417–423, 1984PubMedGoogle Scholar
  16. 16.
    Fordtran JS, Walsh JH: Gastric acid secretion rate and buffer content of the stomach after eating. Results in normal subjects and in patients with duodenal ulcer. J Clin Invest 52:645–657, 1973PubMedGoogle Scholar
  17. 17.
    Richardson CT, Walsh JH, Hicks MI, Fordtran JS: Studies on the mechanism of food-stimulated gastric acid secretion in normal subjects. J Clin Invest 58:623–631, 1976PubMedGoogle Scholar
  18. 18.
    Fiddian-Green RG, Pittenger G, Kothary P: Effect of luminal somatostatin on acid secretion and gastrin release. Scand J Gastroenterol 15:305–309, 1980PubMedGoogle Scholar
  19. 19.
    Ligumsky M, Wengrower D, Karmeli F, Rachmilewitz D: Somatostatin release by human gastric mucosa. Studies in peptic ulcer disease and pernicious anemia. Scand J Gastroenterol 23:687–690, 1988PubMedGoogle Scholar
  20. 20.
    Holst JJ, Jensen SL, Knuhtsen S, Nielsen OV, Rehfeld JF: Effects of vagus, gastric inhibitory polypeptide, and HCl on gastrin and somatostatin release from perfused pig antrum. Am J Physiol 244:G515-G522, 1983PubMedGoogle Scholar
  21. 21.
    Jensen SL, Holst JJ, Christiansen LA, Shokokh-amiri MH, Lorentsen M, Beck H, Jensen HE: Effect of intragastric pH on antral gastrin and somatostatin release in anaesthetised, atropinized duodenal ulcer patients and controls. Gut 28:206–209, 1987PubMedGoogle Scholar

Copyright information

© Plenum Publishing Corporation 1994

Authors and Affiliations

  • Zafer Ferahköşe
    • 1
  • Hüseyn Altinyollar
    • 1
  • B. Bülent Menteş
    • 1
  1. 1.From the Department of SurgeryGazi University Medical SchoolAnkaraTurkey

Personalised recommendations