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Digestive Diseases and Sciences

, Volume 39, Issue 10, pp 2127–2133 | Cite as

Does omeprazole (Prilosec) improve respiratory function in asthmatics with gastroesophageal reflux?

A double-blind, placebo-controlled crossover study
  • John H. Meier
  • Peter R. McNally
  • Madhukar Punja
  • Stephen R. Freeman
  • Robert H. Sudduth
  • Nancy Stocker
  • Michael Perry
  • Harry S. Spaulding
Esophageal, Gastric, And Duodenal Disorders

Abstract

Gastroesophageal reflux (GER) is common among patients with asthma, and it has been speculated that high GER may exacerbate asthma in some. This study was designed to determine if suppression of acid reflux in patients with asthma would improve pulmonary function. A double-blind, placebo-controlled crossover study design was used to determine the effect of GER suppression with omeprazole (20 mg twice daily) on pulmonary function among asthmatic patients with esophagitis. Four of 15 (27%) asthma patients with GER were shown to have a≥20% net improvement in pulmonary function (FEV1) after treatment for six weeks with omeprazole. These results indicate that some patients with asthma and GER will have improved pulmonary function when acid GER is treated with omeprazole.

Key Words

asthma gastroesophageal reflux esophagitis omeprazole 

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Copyright information

© Plenum Publishing Corporation 1994

Authors and Affiliations

  • John H. Meier
    • 1
  • Peter R. McNally
    • 1
  • Madhukar Punja
    • 1
  • Stephen R. Freeman
    • 1
  • Robert H. Sudduth
    • 1
  • Nancy Stocker
    • 1
  • Michael Perry
    • 1
  • Harry S. Spaulding
    • 1
  1. 1.From the Department of Medicine and Services of Gastroenterology, Allergy/Immunology, Pharmacology, and PulmonaryFitzsimons Army Medical CenterAurora

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