The significance of C3 and C4 complement levels in lupus nephritis
- 661 Downloads
C3 and C4 serum complement component levels were examined during various stages of disease activity in 14 SLE patients. It was found that C3 levels were more sensitive index of disease activity than those of C4. C3 levels lower than C4 as expressed by a C3/C4<0.5 were found in 25% of the examined disease episodes; they were only observed in patients with renal involvement during or next to periods of disease activity. We suggest that such a pattern of C3 and C4 when found during the follow-up of SLE patients indicates active renal disease, and implies the recruitment of the alternate pathway for the activation of the complement system.
KeywordsRenal Disease Nephritis Lupus Nephritis Alternate Pathway Sensitive Index
Unable to display preview. Download preview PDF.
- 4.Dixon, W. J., Massey, F. J., Jr.: Introduction to Statistical Analysis. McGraw-Hill, New York 1969.Google Scholar
- 7.Gotze, O., Muller-Eberhard, H. J.: The C3 activatcr system; an alternate pathway of complement activation.J. Exp. Med. 134, 90 (1971).Google Scholar
- 10.Miyasato, F., Pollak, V. E., Burcelo, R.: Serum beta1A (beta1C) globulin in systemic lupus erythematosus: their relationship to clinical and renal histological findings.Arthritis Rheum. 9, 308 (1966).Google Scholar
- 11.Oyama, J. H.: Diagnosis and treatment of lupus nephritis.Med. Clin. N. A. 55, 71 (1971).Google Scholar
- 12.Petz, L. D., Sharp, G. C., Cooper, N. R., Irvin, W. S.: Serum and cerebral spinal fluid complement and serum autoantibodies in systemic lupus erythematosus.Medicine, 50, 259 (1970).Google Scholar
- 16.Ruddy, S., Hunsicker, L. G., Schur, P. H., Austen, K. F.: Abnormality of the alternate complement pathway in systemic lupus erythematosus and hypocomplementemic chronic glomerulonephritis.J. Clin. Invest. 51, 82 (1972).Google Scholar