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International Urology and Nephrology

, Volume 6, Issue 3–4, pp 233–238 | Cite as

The significance of C3 and C4 complement levels in lupus nephritis

  • Y. Levo
  • A. I. Pick
Article

Abstract

C3 and C4 serum complement component levels were examined during various stages of disease activity in 14 SLE patients. It was found that C3 levels were more sensitive index of disease activity than those of C4. C3 levels lower than C4 as expressed by a C3/C4<0.5 were found in 25% of the examined disease episodes; they were only observed in patients with renal involvement during or next to periods of disease activity. We suggest that such a pattern of C3 and C4 when found during the follow-up of SLE patients indicates active renal disease, and implies the recruitment of the alternate pathway for the activation of the complement system.

Keywords

Renal Disease Nephritis Lupus Nephritis Alternate Pathway Sensitive Index 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Akadémiai Kiadó 1974

Authors and Affiliations

  • Y. Levo
    • 1
    • 2
    • 3
    • 4
  • A. I. Pick
    • 1
    • 2
    • 3
    • 4
  1. 1.Department of Medicine BBeilinson HospitalPetah TikvaIsrael
  2. 2.Section of Clinical ImmunologyBeilinson HospitalPetah TikvaIsrael
  3. 3.Rogoff Institute for Medical ResearchBeilinson HospitalPetah TikvaIsrael
  4. 4.Sackler Medical SchcolTel Aviv UniversityTel AvivIsrael

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