Digestive Diseases and Sciences

, Volume 41, Supplement 12, pp 126S–130S

Interferon-α therapy for chronic hepatitis C in special patient populations

  • Patrick Marcellin
  • Nathalie Boyer
  • Jean-Pierre Behamou
  • Serge Erlinger
Article

DOI: 10.1007/BF02087888

Cite this article as:
Marcellin, P., Boyer, N., Behamou, JP. et al. Digest Dis Sci (1996) 41(Suppl 12): 126S. doi:10.1007/BF02087888

Abstract

Interferon-α therapy for chronic hepatitis C in special patient populations raises a number of issues. Patients with hemophilia, kidney disease requiring hemodialysis, mixed cryoglobulinemia, HIV infection, and those receiving an allograft share some characteristics that complicate the treatment of hepatitis C virus infections. These patients generally have some degree of immune deficiency, higher levels of hepatitis C virus replication, and are infected with genotypes 1a or 1b. Each of these characteristics is often associated with a poor response to interferon therapy. Clinical research in this area also has been limited. Current data and clinical experience demonstrate that interferon-α therapy should be considered in patients with hemophilia who have concurrent hepatitis C viral infection. Other hepatitis C virus-infected patient populations in which interferon-α therapy may be beneficial include those undergoing hemodialysis, mixed cryoglobulinemia, or HIV infection. Further, the high incidence of relapse following treatment cessation in these patients warrants prolonged administration of interferon-α. Patients undergoing renal or hepatic allograft transplantation who develop hepatitis C virus infections are not as likely to benefit from interferon-α therapy. These patients may be at risk for allograft rejection during interferon treatment.

Key words

interferon-α hemodialysis allograft transplantation mixed cryoglobulinemia human immunodeficiency virus hepatitis C virus 

Copyright information

© Plenum Publishing Corporation 1996

Authors and Affiliations

  • Patrick Marcellin
    • 1
  • Nathalie Boyer
    • 1
  • Jean-Pierre Behamou
    • 1
  • Serge Erlinger
    • 1
  1. 1.From the Service d'Hépatologie and INSERM U24Hôpital BeaujonClichyFrance
  2. 2.Service d'Hépatologie, Pavillon SergentHôpital BeaujonClichy CedexFrance

Personalised recommendations