Digestive Diseases and Sciences

, Volume 39, Issue 12, pp 2595–2600

Oral bacteriotherapy for viral gastroenteritis

  • Erika Isolauri
  • Minna Kaila
  • Hannu Mykkänen
  • Wen Hua Ling
  • Seppo Salminen
Intestinal Disorders, Inflammatory Bowel Disease, Immunology, And Microbiology

DOI: 10.1007/BF02087695

Cite this article as:
Isolauri, E., Kaila, M., Mykkänen, H. et al. Digest Dis Sci (1994) 39: 2595. doi:10.1007/BF02087695

Abstract

The effect of orally administered lactobacilli on acute rotavirus diarrhea was tested in 42 well-nourished children ages 5–28 months. After oral rehydration, the patients were randomized to a study group, receiving humanLactobacillus casei strain GG 1010 colony-forming units twice daily for five days, or a control group not given lactobacilli.Lactobacillus GG was found in the feces in 83% of the study group. The diarrheal phase was shortened in that group. Dietary supplementation with lactobacilli significantly influenced the bacterial enzyme profile: urease activity during diarrhea transiently increased in the control group but not in the study group;F=8.6,P=0.01. No intergroup differences were found in β-glucuronidase, β-glucosidase, and glycocholic acid hydrolase levels. We suggest that rotavirus infection gives rise to biphasic diarrhea, the first phase being an osmotic diarrhea and the second associated with overgrowth of specifically urease-producing bacteria. Oral bacteriotherapy appears a promising means to counteract the disturbed microbial balance.

Key words

infantile diarrhea rotavirus infections Lactobacillus casei clinical 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Plenum Publishing Corporation 1994

Authors and Affiliations

  • Erika Isolauri
    • 1
    • 2
    • 3
    • 4
  • Minna Kaila
    • 1
    • 2
    • 3
    • 4
  • Hannu Mykkänen
    • 1
    • 2
    • 3
    • 4
  • Wen Hua Ling
    • 1
    • 2
    • 3
    • 4
  • Seppo Salminen
    • 1
    • 2
    • 3
    • 4
  1. 1.Department of Clinical NutritionUniversity of KuopioFinland
  2. 2.Department of PhysiologyUniversity of KuopioFinland
  3. 3.Department of Biochemistry and Food ChemistryUniversity of TurkuFinland
  4. 4.Department of Clinical MedicineUniversity of TampereTampereFinland

Personalised recommendations