Digestive Diseases and Sciences

, Volume 39, Issue 5, pp 1014–1024

Disproportionate ileal digestion on canine food consumption

A possible model for satiety in pancreatic insufficiency
  • J. H. Meyer
  • J. D. Elashoff
  • J. E. Doty
  • Y. G. Gu
Article

Abstract

In animals, ileal sensors of nutrients signal satiety more potently than similar sensors in jejunum. We postulated that inadequate food intake and weight loss in human pancreatic insufficiency might arise by the displacement of digestion to ileum, where excessive release of digestive products would enhance satiety. To test this idea, we studied dogs prepared with pancreatic fistulas, which allowed reversible switching of pancreatic juice from entry at duodenum to entry at mid-small intestine. Dogs were studied in a crossover design over successive eight-day periods. Food consumption and body weight were measured while the dogs had continuous access to food. Diversion of pancreatic juice to mid-intestine significantly (P<0.01) depressed food intake by an average of 28%. Diversion also significantly (P<0.01) reduced body weight. The findings support the idea that insufficient food intake in human pancreatic insufficiency may result from stimulation of ileal satiety mechanisms.

Key words

satiety ileal sensors maldigestion pancreatic insufficiency 

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Copyright information

© Plenum Publishing Corporation 1994

Authors and Affiliations

  • J. H. Meyer
    • 1
    • 2
    • 3
  • J. D. Elashoff
    • 1
    • 2
    • 3
  • J. E. Doty
    • 1
    • 2
    • 3
  • Y. G. Gu
    • 1
    • 2
    • 3
  1. 1.From the Department of Medicine and SurgerySepulveda VA Medical CenterUSA
  2. 2.the Biostatistics UnitCedars Sinai Medical CenterUSA
  3. 3.the UCLA School of MedicineUSA
  4. 4.111G, VA Medical CenterSepulveda

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