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Digestive Diseases and Sciences

, Volume 39, Issue 4, pp 834–842 | Cite as

Effect of resistant starch on colonic fermentation, bile acid metabolism, and mucosal proliferation

  • Ivo P. van Munster
  • Albert Tangerman
  • Fokko M. Nagengast
Original Articles

Abstract

Resistant starch is by definition that part of starch that escapes digestion in the small bowel. Cecal fermentation of resistant starch into short-chain fatty acids will result subsequently in a decrease in pH. Thus, resistant starch may have the same effect on colonic luminal contents and mucosa as some fiber components. We studied the effects of adding 45 g native amylomaize (Hylon-VII) to a standardized diet in 14 healthy volunteers on fermentation and colonic mucosal proliferation. Hylon-VII is a high amylose maize starch, containing 62% resistant starch. During amylomaize consumption, breath hydrogen excretion rose 85% and fecal short chain fatty acid output increased 35% (P<0.01). Excretion of primary bile acids increased and the soluble deoxycholic acid concentration decreased by 50% (P=0.002). Subsequently, cytotoxicity of the aqueous phase of feces—as measured on a colon cancer cell line—decreased (P=0.007). Colonic mucosal proliferation in rectal biopsies (proliferating cell nuclear antigen immunostaining) decreased from 6.7 to 5.4% (P=0.05). We speculate that resistant starch consumption decreases colonic mucosal proliferation as a result of the decreased formation of cytotoxic secondary bile acids, which is possibly mediated through acidification of the large bowel by production of short-chain fatty acids.

Key words

colon cancer fermentation resistant starch bile acids proliferation 

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Copyright information

© Plenum Publishing Corporation 1994

Authors and Affiliations

  • Ivo P. van Munster
    • 1
    • 2
  • Albert Tangerman
    • 1
    • 2
  • Fokko M. Nagengast
    • 1
    • 2
  1. 1.From the Department of Internal MedicineGroot Ziekengasthuis,'s-HertogenboschThe Netherlands
  2. 2.Department of Medicine, Division of GastroenterologyUniversity Hospital NijmegenNijmegenThe Netherlands

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