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Pharmaceutisch Weekblad

, Volume 8, Issue 2, pp 134–138 | Cite as

High pressure liquid Chromatographic determination of carbocisteine in human plasma and urine

Original Articles

Abstract

A method is described for the direct analysis of the amino acid carbocisteine in plasma and urine samples, following reaction with dabsyl chloride. Dabsylated carbocisteine is subjected to high pressure liquid chromatography with spectrophotometric detection at 425 nm. The usefulness of the method for bioavailability studies is discussed and compared with methods currently in use.

Key words

Carbocisteine Derivatization High pressure liquid chromatography Plasma Quantitative analysis Urine 

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Copyright information

© Bohn, Scheltema & Holkema 1986

Authors and Affiliations

  • J. Bron
    • 1
  1. 1.Cedona Pharmaceuticals BVRW HaarlemThe Netherlands

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