Experientia

, Volume 37, Issue 10, pp 1090–1092 | Cite as

Interactions ofΔ11-tetrahydrocannabinol with cannabinol and cannabidiol following oral administration in man. Assay of cannabinol and cannabidiol by mass fragmentographywith cannabinol and cannabidiol following oral administration in man. Assay of cannabinol and cannabidiol by mass fragmentography

  • S. Agurell
  • S. Carlsson
  • J. E. Lindgren
  • A. Ohlsson
  • H. Gillespie
  • L. Hollister

Summary

Oral administration to man of 20 mgΔ11-tetrahydrocannabinol (THC) together with placebo or 40 mg cannabinol (CBN) or 40 mg cannabidiol (CBD) gave evidence of a possible limited interaction of THC with CBN but not with CBD as indicated by average plasma THC levels. Peak CBD and CBN concentrations were similar to that of THC, viz. about 5–8 ng/ml.

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Copyright information

© Birkhäuser Verlag 1981

Authors and Affiliations

  • S. Agurell
    • 1
    • 2
    • 3
  • S. Carlsson
    • 1
    • 2
    • 3
  • J. E. Lindgren
    • 1
    • 2
    • 3
  • A. Ohlsson
    • 1
    • 2
    • 3
  • H. Gillespie
    • 1
    • 2
    • 3
  • L. Hollister
    • 1
    • 2
    • 3
  1. 1.Department of PharmacologyKarolinska InstituteStockholm(Sweden)
  2. 2.Astra Läkemedel ABSödertälje(Sweden)
  3. 3.Veterans Administration HospitalPalo AltoUSA

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