European Journal of Pediatrics

, Volume 154, Issue 8, pp 658–661 | Cite as

Floating-Harbor syndrome: description of a further patient, review of the literature, and suggestion of autosomal dominant inheritance

  • D. Lacombe
  • M. A. Patton
  • C. Elleau
  • J. Battin
Original Paper



The Floating-Harbor syndrome is a growth retardation syndrome with delayed bone age, speech development, and typical facial features. The face is triangular with deep-set eyes, long eyelashes, bulbous nose, wide columella, short philtrum, and thin lips. We present an additional patient and review 16 cases from the literature. The possible phenotype in the patient's mother suggests a dominant mode of inheritance for the syndrome.


The Floating Harbor syndrome is a growth deficiency syndrome characterized by proportionate short stature, characteristic face and delayed speech development. Inheritance is possibly autosomal dominant.

Key words

Floating-Harbor syndrome Growth retardation Dysmorphology Genetics 



Floating Harbor syndrome


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  1. 1.
    Chudley AE, Moroz SP (1991) Floating-Harbor syndrome and celiac disease. Am J Med Genet 38: 562–564PubMedGoogle Scholar
  2. 2.
    Gorlin RJ, Cohen MM Jr, Levin LS (1990) Unusual facies, short stature, and hypoplastic penis (Floating-Harbor syndrome, Pelletier-Leisti syndrome). In: Motulsky AG, Bobrow M, Harper PS, Seriver C (eds) Syndromes of the head and neck, 3rd edn. Oxford University Press, Oxford, p 914Google Scholar
  3. 3.
    Houlston RS, Collins AL, Dennis NR, Temple IK (1994) Further observations on the Floating-Harbor syndrome. Clin Dysmorphol 3: 143–149PubMedGoogle Scholar
  4. 4.
    Leisti J, Hollister DW, Rimoin DL (1974) Case report 2. The Floating-Harbor syndrome. Synd Ident 2: 305Google Scholar
  5. 5.
    Lipson A (1991) Floating-Harbor and the good ship Shprintzen (Letter). J Med Genet 28: 807–808Google Scholar
  6. 6.
    Majewski F, Lenard HG (1991) The Floating-Harbor syndrome. Eur J Pediatr 150: 250–252PubMedGoogle Scholar
  7. 7.
    Patton MA, Hurst J, Donnai D, McKeown CME, Cole T, Goodship J (1991) Syndrome of the month: Floating-Harbor syndrome. J Med Genet 28: 201–204PubMedGoogle Scholar
  8. 8.
    Pelletier G, Feingold M (1973) Case report. Synd Ident 1: 8–9Google Scholar
  9. 9.
    Robinson PL, Shohat M, Winter RM, Conte WJ, Gordon-Nesbitt D, Feingold M, Laron Z, Rimoin DL (1988) A unique association of short stature, dysmorphic features, and speech impairment (Floating-Harbor syndrome). J Pediatr 113: 703–706PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • D. Lacombe
    • 1
  • M. A. Patton
    • 2
  • C. Elleau
    • 3
  • J. Battin
    • 1
  1. 1.Department of Paediatric GeneticsPellegrin-Children's HospitalBordeaux CédexFrance
  2. 2.S. W. Thames Regional Genetics ServiceSt George's HospitalLondonUK
  3. 3.Department of PaediatricsCHG Mont-de-MarsanFrance

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