, Volume 61, Issue 2–3, pp 55–59 | Cite as

Treatment of refractory multiple myeloma with the vincristine-adriamycin-dexamethasone (VAD) regimen

  • W. Stenzinger
  • A. Blömker
  • W. Hiddemann
  • J. van de Loo
Original article


Seventeen patients with advanced refractory multiple myeloma were treated with a 4-day continuous infusion of vincristine and adriamycin in combination with 4-day intermittent high-dose dexamethasone (VAD). Ten patients entered a partial remission (59%). Complete remission was not achieved in any patients. The median response duration was 11 months and the median survival of the responding patients was 18 months versus 5 months for non-responders. Major complications during VAD treatment were infections probably due to a combination of myelosuppression and intensive corticosteroid therapy. The VAD regimen offers a useful chemotherapy that produces an overall high response rate even in intensively pretreated patients resistant to first line therapy. The treatment results in a clear tendency to longer survival in responding patients.

Key words

Multiple myeloma Refractoriness Chemotherapy VAD regimen 


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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • W. Stenzinger
    • 1
  • A. Blömker
    • 1
  • W. Hiddemann
    • 1
  • J. van de Loo
    • 1
  1. 1.Department of Internal MedicineUniversity of MünsterMünsterFederal Republic of Germany

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