European Journal of Pediatrics

, Volume 155, Issue 2, pp 117–119

Endogenous tissue plasminogen activator in neonatal cerebrospinal fluid

  • Andrew Whitelaw
  • Marie-Christine Mowinckel
  • Vineia Fellman
  • Ulrich Abildgaard

DOI: 10.1007/BF02075763

Cite this article as:
Whitelaw, A., Mowinckel, MC., Fellman, V. et al. Eur J Pediatr (1996) 155: 117. doi:10.1007/BF02075763


Tissue type plasminogen activator (tPA) plays a role in differentiation of neurones and activity-dependent structural changes in neurones. We hypothesised that tPA would also be present in CSF during fibrinolysis after intraventricular haemorrhage. We measured tPA antigen in CSF from 13 normal newborn infants and 14 infants with posthaemorrhagic ventricular dilation (PHVD). tPA was undetectable or at the limit of detection (1 μg/l) in normal CSF. The CSF tPA concentration ranged from 1.3 to 3.5 μg/l in the infants with PHVD. Serial tapping in one infant showed persistence of tPA in the CSF from 3 to 8 weeks of age. We conclude that endogenous tPA may be part of the physiological response to intraventricular haemorrhage or may be present as a result of passive diffusion into the CSF.

Key words

Newborn infant Plasminogen activator Cerebrospinal fluid Intraventricular haemorrhage Hydrocephalus 



intraventricular haemorrhage


long-term potentiation


post-haemorrhagic ventricular dilatation


tissue plasminogen activator


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Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • Andrew Whitelaw
    • 1
  • Marie-Christine Mowinckel
    • 2
  • Vineia Fellman
    • 3
  • Ulrich Abildgaard
    • 2
  1. 1.Paediatric DepartmentAker University HospitalOsloNorway
  2. 2.Haematology Research Laboratory, Aker HospitalUniversity of OsloOsloNorway
  3. 3.Children's HospitalUniversity of HelsinkiHelsinkiFinland

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