Endogenous tissue plasminogen activator in neonatal cerebrospinal fluid
- Cite this article as:
- Whitelaw, A., Mowinckel, MC., Fellman, V. et al. Eur J Pediatr (1996) 155: 117. doi:10.1007/BF02075763
Tissue type plasminogen activator (tPA) plays a role in differentiation of neurones and activity-dependent structural changes in neurones. We hypothesised that tPA would also be present in CSF during fibrinolysis after intraventricular haemorrhage. We measured tPA antigen in CSF from 13 normal newborn infants and 14 infants with posthaemorrhagic ventricular dilation (PHVD). tPA was undetectable or at the limit of detection (1 μg/l) in normal CSF. The CSF tPA concentration ranged from 1.3 to 3.5 μg/l in the infants with PHVD. Serial tapping in one infant showed persistence of tPA in the CSF from 3 to 8 weeks of age. We conclude that endogenous tPA may be part of the physiological response to intraventricular haemorrhage or may be present as a result of passive diffusion into the CSF.
Key wordsNewborn infant Plasminogen activator Cerebrospinal fluid Intraventricular haemorrhage Hydrocephalus
post-haemorrhagic ventricular dilatation
tissue plasminogen activator
Unable to display preview. Download preview PDF.