Advertisement

Pharmaceutisch Weekblad

, Volume 9, Supplement 1, pp S90–S92 | Cite as

Treatment of chronic postsurgical osteomyelitis with ciprofloxacin

  • J. A. A. Hoogkamp-Korstanje
Article
  • 18 Downloads

Abstract

Sixteen patients (11F, 5M, age 18–83, mean 59.8 years) with chronic postsurgical osteomyelitis were treated with ciprofloxacin. The dosage was 500 or 750 mg twice daily orally during one to six months; four patients started with 300 mg twice daily intravenously and changed after 3–7 days to oral therapy. Twelve patients had implanted prostheses. The organisms involved wereEnterobacteriaceae (11),Pseudomonas aeruginosa (7),Staphylococcus aureus (5),Streptococcus faecalis (4) andBacteroides fragilis (1). Nine patients had pure cultures, seven mixed cultures.

Cure (disappearance of infection symptoms, return of normal function with negative cultures, without resurgery) was obtained in 11 patients, improvement (resurgery required to obtain complete cure) in two. Three patients with infections byStaphylococcus aureus (2) andPseudomonas aeruginosa (1) failed to respond after one and four months treatment respectively. No side effects were observed.

Key words

Chronic -osteomyelitis Ciprofloxacin Concentration in pus Prosthesis 

References

  1. 1.
    Waldvogel FA, Medoff G, Swartz MN. Osteomyelitis: a review of clinical features, therapeutic considerations and unusual aspects. New Engl J Med 1970;282:198–206.PubMedGoogle Scholar
  2. 2.
    Dellamonica P et al. Pefloxacin bone diffusion, clinical study. 14th International congress of chemotherapy, Kyoto, Japan, 1985:WS7–15.Google Scholar
  3. 3.
    Fong IW et al. Penetration of ciprofloxacin after single oral doses in normal and infected bones. 1st International ciprofloxacin workshop, Leverkusen 1985. Current Clinical Practice Series 34, p 201–3. Excerpta Medica, Amsterdam.Google Scholar
  4. 4.
    Gilbert DN, Tice AD, Marsh PK, Craven PC, Preheim LC. Oral ciprofloxacin therapy for chronic contiguous osteomyelitis caused by aerobic gram-negative bacilli. Am J Med 1987;82(4a):254–8.PubMedGoogle Scholar
  5. 5.
    Hessen MT et al. Clinical efficacy of ciprofloxacin therapy for gramnegative bacillary osteomyelitis. Am J Med 1987;82(4a):262–5.PubMedGoogle Scholar
  6. 6.
    Lefrock JL, Carr BB. Clinical experience with cefotaxime in the treatment of serious bone and joint infections. Rev Infect Dis 1982;45:465–71.Google Scholar
  7. 7.
    Dutoy JP, Wauters G. The treatment of bone infections with ceftazidime J. Antimicr Chemoth 1983;12SA:229–33.Google Scholar
  8. 8.
    Greenberg RN et al. Randomised trial of ciprofloxacin compared with other antimicrobial therapy in the treatment of osteomyelitis. Am J Med 1987;82(4a):266–9.Google Scholar

Copyright information

© Bohn, Scheltema & Holkema 1987

Authors and Affiliations

  • J. A. A. Hoogkamp-Korstanje
    • 1
  1. 1.Laboratory for Public HealthEN LeeuwardenThe Netherlands

Personalised recommendations