Pharmaceutisch Weekblad

, Volume 5, Issue 6, pp 325–328 | Cite as

Computer modelling of the binding of non-selective ligands to biological receptors

  • H. J. Wynne
  • D. De Kaste
  • W. Soudijn
Original Articles


The application of common linearization methods (logprobit analysis or Hill plot transformation) to the evaluation of receptor binding experiments leads to serious errors, if the ligands used possess insufficient receptor selectivity. The use of simultaneous non-linear curvefitting procedures in this case is recommended and illustrated.


Public Health Internal Medicine Computer Modelling Receptor Binding Linearization Method 
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Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1983

Authors and Affiliations

  • H. J. Wynne
    • 1
  • D. De Kaste
    • 2
  • W. Soudijn
    • 2
  1. 1.MaagdenhuisUniversity of AmsterdamWX AmsterdamThe Netherlands
  2. 2.Department of Pharmaceutical ChemistryUniversity of AmsterdamTV AmsterdamThe Netherlands

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