Pharmaceutisch Weekblad

, Volume 5, Issue 6, pp 298–301 | Cite as

Synthesis, physical properties and microbiological activities of more water soluble silver sulfadiazine derivatives

  • P. P. De Wit
  • H. Van Doorne
  • A. Bult
Original Articles


In this study the preparation of five hydrophilic derivatives of sulfadiazine is reported. The common structural element in the compounds is the 2-sulfonamidopyrimidine moiety. Three of these compounds are suitable for the preparation of a photostable 1∶1 silver compound. These silver compounds are five to ten times more water soluble than silver sulfadiazine. TheIr,1H- and13C-Nmr data point to a similar co-ordination of silver in these compounds as with silver sulfadiazine. The microbiological activity of these silver compounds againstSt. aureus is slightly lower.


Public Health Internal Medicine Sulfadiazine Microbiological Activity Silver Compound 
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Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1983

Authors and Affiliations

  • P. P. De Wit
    • 1
  • H. Van Doorne
    • 2
  • A. Bult
    • 1
  1. 1.Department of Pharmaceutical Analysis and Analytical Chemistry, Subfacuity of PharmacyUniversity of LeidenRA LeidenThe Netherlands
  2. 2.Department of Pharmaceutical Technology, Subfaculty of PharmacyUniversity of LeidenRA LeidenThe Netherlands

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