Basic Research in Cardiology

, Volume 78, Issue 4, pp 351–363 | Cite as

Biochemical regulators in cardiac hypertrophy

  • F. Kölbel
  • V. Schreiber
Editorial
Received:

Summary

In recent years research has shown that muscle is capable of reacting to mechanical stimuli by altering biochemical processes. Myocardium is probably the source of a biochemical factor, or factors which activate myocardial protein synthesis. In experimentally induced cardiac hypertrophy adaptive alterations have been shown to occur not only in the adrenal medulla but also in the adrenal cortex. Finally, detection of cross reactivity between digitalis glycosides and a number of steroid hormones has succeeded. We assume that such cross reactivity indicates the existence of an endogenic factor of steroid character, which is produced in the adrenal gland and functions as an endogenic cardiotonic agent. During experimental cardiac hypertrophy its synthesis is possibly increased.

We propose the term “endocardin” or “endocardiotonin” for this agent.

Key words

cardiac hypertrophy protein synthesis digitalis glycosides adrenal cortex digoxin-like immunoreactivity 
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Copyright information

© Dr. Dietrich Steinkopff Verlag 1983

Authors and Affiliations

  • F. Kölbel
    • 1
    • 2
  • V. Schreiber
    • 1
    • 2
  1. 1.Third Medical Department, Faculty of MedicineCharles UniversityPrague 2Czechoslovakia
  2. 2.Laboratory for Endocrinology and Metabolism, Faculty of MedicineCharles UniversityPrague 2Czechoslovakia

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