Journal of Assisted Reproduction and Genetics

, Volume 13, Issue 9, pp 705–708 | Cite as

The predictive value of an initial serum β human chorionic gonadotropin level for pregnancy outcome following in vitro fertilization

  • Suna M. Qasim
  • Carrie Callan
  • Jung K. Choe
Clinical Assisted Reproduction


Purpose: Our purpose was to assess the predictive value for pregnancy outcome of an initial serum quantitative β-hCG measurement obtained 11 or 12 days after embryo transfer in an in vitro fertilization program.

Methods: A prospective, descriptive study of 153 pregnancies achieved via in vitro fertilization-embryo transfer was performed. Initial β-hCG levels and subsequent pregnancy outcomes were compared.

Results: The overall mean initial β-hCG level was 91±85.8 mIU/ml for normal (singleton, multiple-gestation) pregnancies and 29±24.9 mIU/ml for abnormal (miscarriage, ectopic) pregnancies (P<0.01; power, >80%). While 93.9% of patients with initial β-hCG levels ≥42 mIU/ml had normal pregnancies, 56.4% of those with initial levels <42 mIU/ml experienced abnormal outcomes. With 42 mIU/ml as the cutoff level for predicting a normal pregnancy, this screening test yielded a sensitivity of 79.3% and a specificity of 83.8%.

Conclusions: Initial serum β-hCG levels obtained 11 or 12 days after embryo transfer may be predictive of pregnancy outcome in an in vitro fertilization program.

Key words

initial β-human chorionic gonadotropin levels in vitro fertilization pregnancy outcome 


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Copyright information

© Plenum Publishing Corporation 1996

Authors and Affiliations

  • Suna M. Qasim
    • 1
  • Carrie Callan
    • 1
  • Jung K. Choe
    • 1
  1. 1.Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and InfertilityThe Cooper Center for Reproductive Endocrinology, Cooper Hospital/University Medical CenterMarlton

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