Ecological study of association betweenHelicobacter pylori infection and gastric cancer in Taiwan
- 35 Downloads
The association betweenHelicobacter pylori infection and gastric cancer remains controversial. A community-based serosurvey was carried out in Taiwan to investigate the association. Serum IgG antibodies againstHelicobacter pylori were examined in 728 subjects randomly selected from three townships with different gastric cancer mortality rates. The overall seropositivity ofHelicobacter pylori was 54.7% (398/728) with no gender difference (males: 54.5%; females: 54.8%). The seroprevalence ofHelicobacter pylori progressively increased with age in all three study townships. The age-specific seropositivity ofHelicobacter pylori correlated well with age-adjusted gastric cancer mortality in the three townships. The difference in seropositivity was more profound in younger age groups. The ecological study in Taiwan suggests an association betweenHelicobacter pylori infection and gastric cancer.Helicobacter pylori infection in early childhood may be a key issue; in addition, a long induction time appears to be required for gastric carcinogenesis.
Key wordsHelicobacter pylori gastric cancer seroepidemiology
Unable to display preview. Download preview PDF.
- 2.Department of Health, Executive Yuan, Republic of China: Health Statistics, Vol. II. Vital Statistics, 1981–1988. Taipei, Department of Health, 1982–1989Google Scholar
- 5.Forman D, Newell DG, Fullerton F, Yarnell JWG, Stacey SR, Wald N, Sitas F: Association between infection withHelicobacter pylori and risk of gastric cancer: Evidence from a prospective investigation. Br Med J 302:1302–1305, 1991Google Scholar
- 8.Hansson LE, Engstrand L, Evans DJ, Nygrén O Jr:Helicobacter pylori (HP) seropositivity is a risk factor for gastric adenocarcinoma (GAC). Gastroenterology 102(4):A361, 1992 (abstract)Google Scholar
- 15.Wyatt JI, Rathbone BJ: The role of serology in the diagnosis ofCampylobacter pylori infection. Scand J Gastroenterol 24:27–34, 1989Google Scholar