Digestive Diseases and Sciences

, Volume 40, Issue 4, pp 709–716

Current theories of pathogenesis and treatment of nonocclusive mesenteric ischemia

  • Michael G. Wilcox
  • Thomas J. Howard
  • Lora A. Plaskon
  • Joseph L. Unthank
  • James A. Madura
Ischemia-Reperfusion

Abstract

Nonocclusive mesenteric ischemia (NOMI) is a poorly understood condition marked by progressive intestinal ischemia leading to infarction, sepsis, and death in a high proportion of patients. The mortality rate for this intestinal disorder remains high, even when the diagnosis is made early in the disease course. This paper presents a comprehensive review of NOMI with a detailed discussion of its history, pathophysiology, diagnosis, and treatment.

Key words

mesenteric ischemia vasoconstriction ischemia-reperfusion injury enteral feedings autoregulation intestinal infarction 

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Copyright information

© Plenum Publishing Corporation 1995

Authors and Affiliations

  • Michael G. Wilcox
    • 1
  • Thomas J. Howard
    • 1
  • Lora A. Plaskon
    • 1
  • Joseph L. Unthank
    • 1
  • James A. Madura
    • 1
  1. 1.From the Department of SurgeryIndiana University School of MedicineIndianapolis

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