Journal of Chemical Ecology

, Volume 20, Issue 2, pp 293–302

Identification of the antibiotic phomalactone from the entomopathogenic fungusHirsutella thompsonii var.synnematosa

  • Stuart B. Krasnoff
  • Sandeep Gupta

DOI: 10.1007/BF02064437

Cite this article as:
Krasnoff, S.B. & Gupta, S. J Chem Ecol (1994) 20: 293. doi:10.1007/BF02064437


Dichloromethane extracts of culture broth from three strains of the entomopathogenic fungusHirsutella thompsonii var.synnematosa were toxic to two species of tephritid fruit fly and inhibited conidial germination in vitro in several other entomopathogenic fungi includingBeauveria bassiana, Tolypocladium spp., andMetarhizium anisopliae. A major metabolite, toxic to apple maggot,Rhagoletis pomonella, and inhibitory to conidial germination inB. bassiana, was isolated and identified as the antibiotic (+)-phomalactone, 6-(1-propenyl)-5,-6-dihydro-5-hydroxypyran-2-one. This is the first biologically active compound of low molecular weight isolated from the genusHirsutella.

Key Words

Beauveria Ceratitis capitata Medfly conidial germination inhibitor entomopathogenic fungus fungal toxin Hirsutella Metarhizium mycotoxin phomalactone Rhagoletis pomonella Diptera Tephritidae 

Copyright information

© Plenum Publishing Corporation 1994

Authors and Affiliations

  • Stuart B. Krasnoff
    • 1
  • Sandeep Gupta
    • 1
    • 2
  1. 1.USDA-ARS, U.S. Plant, Soil, and Nutrition LaboratoryIthaca
  2. 2.Boyce Thompson InstituteIthaca
  3. 3.ISK Mountain View Research Center, Inc.Sunnyvale

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