Digestive Diseases and Sciences

, Volume 40, Issue 3, pp 590–597

Treatment of erosive reflux esophagitis resistant to H2-receptor antagonist therapy

Lansoprazole, a new proton pump inhibitor
  • Malcolm Robinson
  • Donald R. Campbell
  • Stephen Sontag
  • Seymour M. Sabesin
Esophageal, Gastric, And Duodenal Disorders

DOI: 10.1007/BF02064376

Cite this article as:
Robinson, M., Campbell, D.R., Sontag, S. et al. Digest Dis Sci (1995) 40: 590. doi:10.1007/BF02064376

Abstract

Fifty-four patients with endoscopically documented therapy-resistant erosive reflux esophagitis were treated with lansoprazole, a new proton pump inhibitor, for up to 12 weeks. Prior to entry, all had remained unhealed after treatment with at least two histamine2-receptor antagonists, at therapeutic doses or higher, for at least 12 weeks. Patients were randomized to receive either 30 or 60 mg lansoprazole once daily. Endoscopy was performed and symptoms assessed at weeks 2, 4, 6, 8, and 12. Fifty-nine percent of the 50 evaluable patients were healed (ie, no evidence of erosions) after only two weeks of lansoprazole. Cumulative endoscopic healing rates were 82% and 92% by week 4 and week 8, respectively, and the two doses were equally effective in healing. The 30- and 60-mg doses effected a decrease in the overall symptom score from 5.30 and 4.85 to 2.35 and 1.67, respectively, by the final treatment visit (P=0.001). No clinically significant adverse events or changes in laboratory parameters were observed, and no patients withdrew prematurely from the study. This study demonstrates that lansoprazole therapy is highly effective in healing erosive reflux esophagitis resistant to therapy with histamine H2-receptor antagonists.

Key Words

lansoprazole erosive reflux esophagitis proton pump inhibitor acid secretion inhibition 

Copyright information

© Plenum Publishing Corporation 1995

Authors and Affiliations

  • Malcolm Robinson
    • 1
    • 2
    • 3
    • 4
  • Donald R. Campbell
    • 1
    • 2
    • 3
    • 4
  • Stephen Sontag
    • 1
    • 2
    • 3
    • 4
  • Seymour M. Sabesin
    • 1
    • 2
    • 3
    • 4
  1. 1.From the Oklahoma Foundation for Digestive Research, Department of MedicineUniversity of Oklahoma College of MedicineOklahoma City
  2. 2.University of Kansas School of Medicine and Department of Veterans Affairs Medical CenterKansas City
  3. 3.Veterans Affairs Edward Hines Jr. HospitalHines
  4. 4.Rush-Presbyterian St. Luke's Medical CenterChicago

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