Digestive Diseases and Sciences

, Volume 40, Issue 11, pp 2341–2348 | Cite as

Serum interleukin-6, interleukin-8, andβ2-Microglobulin in early assessment of severity of acute pancreatitis comparison with serum C-reactive protein

  • Raffaele Pezzilli
  • Paola Billi
  • Rita Miniero
  • Manuela Fiocchi
  • Onda Cappelletti
  • Antonio Maria Morselli-Labate
  • Bahjat Barakat
  • Giuseppe Sprovieri
  • Mario Miglioli
Pancreatic And Biliary Disordes


The aim of this study was to compare the sensitivity, specificity, and diagnostic accuracy of serum interleukin-6, interleukin-8,β2-microglobulin, and C-reactive protein in the assessment of the severity of acute pancreatitis using commercial kits for their respective assays. Thirty-eight patients with acute pancreatitis (25 men, 13 women, mean age 59 years, range 16–97) were studied; the diagnosis was based on prolonged upper abdominal pain associated with a twofold increase of serum lipase, and it was confirmed by imaging techniques. According to the Atlanta criteria, 15 patients had severe illness and 23 had mild disease. The four serum markers were determined in all patients on admission, as well as daily for the following five days. On the first day of the disease, the sensitivity (calculated on patients with severe pancreatitis), specificity (calculated on patients with mild pancreatitis), and the diagnostic accuracy of these serum markers for establishing the severity of acute pancreatitis were 100%, 86%, and 91% for interleukin-6 (cutoff level 2.7 pg/ml); 100%, 81%, and 88% for interleukin-8 (cutoff level 30 pg/ml); 58%, 81%, and 73% forβ2-microglobulin (cutoff level 2.1 mg/liter); and 8%, 95%, and 64% for C-reactive protein (cutoff level 11 mg/dl). The results of our study indicate that, when assayed during the first 24 hr of disease onset, interleukin-6 and interleukin-8 are better markers thanβ2-microglobulin or C-reactive protein for evaluating the severity of acute pancreatitis.

Key words

interleukin-6 interleukin-8 β2-microglobulin C-reactive protein acute pancreatitis 


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Copyright information

© Plenum Publishing Corporation 1995

Authors and Affiliations

  • Raffaele Pezzilli
    • 1
  • Paola Billi
    • 1
  • Rita Miniero
    • 1
  • Manuela Fiocchi
    • 1
  • Onda Cappelletti
    • 1
  • Antonio Maria Morselli-Labate
    • 1
  • Bahjat Barakat
    • 1
  • Giuseppe Sprovieri
    • 1
  • Mario Miglioli
    • 1
  1. 1.From the Medicina d'Urgenza e Pronto Soccorso, Laboratorio CentralizzatoIstituto di Clinica Medica e Gastroenterologia, Ospedale S. OrsolaBolognaItaly

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