, Volume 45, Issue 3–4, pp 243–251 | Cite as

Occurrence of atypical lymphocytes following intravenous injection of Candida albicans in mice

  • Z. Thaddeus Mankowski


The occurrence of atypical lymphocytes has been observed in the course of experimental acute infection withCandida albicans in mice. In animals injected intravenously with 2.5 × 106 ofCandida albicans cells, an increased number of monocytes was seen in 24 hours. Monocytes showed toxic vacuolisation in most instances in protoplasm and sometimes in the nuclei. Only a few atypical lymphocytes could be seen at that time. In the following days the number of monocytes diminished and the number of atypical lymphocytes increased. After four days atypical lymphocytes constituted frequently over 20 % of white cells. The autopsy of sacrificed or dead animals with the presence of such elevated percentages of atypical lymphocytes showed enlargement of cervical lymphnodes in all animals. In mice infected with 1.4 × 103 ofCandida albicans cells, no level higher than 12% of atypical lymphocytes was seen. Pictures were returning to normal with only a few atypical lymphocytes present among the animals which survived for two months after infection withCandida albicans.


Candida Intravenous Injection Candida Albicans Cervical Lymphnodes Acute Infection 
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Copyright information

© Dr. W. Junk N.V. 1971

Authors and Affiliations

  • Z. Thaddeus Mankowski
    • 1
  1. 1.Western Institute for Cancer and Leukemia ResearchSanta Monica

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