Die Bedeutung der Xanthinoxydase für den Eisenstoffwechsel

  • G. Strohmeyer
  • O. Chearanai
  • H. Goebell
Article
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Zusammenfassung

  1. 1.

    Bei 6 Wochen eisenarm ernährten wachsenden Ratten kommt es zu einer Abnahme der Xanthinoxydase(XOD)-Aktivität in der Leber und Darmmucosa, zu einer Reduzierung des Depoteisens in der Leber und zu einer Eisenmangelanämie.

     
  2. 2.

    Allopurinol hemmt die XOD-Aktivität hauptsächlich in der Leber; die XOD-Aktivität in der Darmmucosa bleibt unter den gewählten experimentellen Bedingungen unverändert. Die Eisenresorption wird durch die Änderung der XOD-Aktivität nicht beeinflußt. Unter Allopurinol kommt es zu einer Zunahme des chemisch bestimmten Nichthämineisens in der Leber. Histologisch war keine Siderose der Leber erkennbar.

     
  3. 3.

    Unter Allopurinol sinkt außer der XOD auch die Aktivität der Glycerin-Aldehyd-3-Phosphatdehydrogenase (GAPDH) in der Leber signifikant ab, während die Nichthämineisenkonzentration zunimmt. Der Eisenstoffwechsel wird nicht direkt durch die Aktivität der XOD reguliert. Allopurinol hat wahrscheinlich nur eine unspezifische Wirkung auf den Eisenstoffwechsel der Leber.

     

Schlüsselwörter

Xanthinoxydase Allopurinol Eisenstoffwechsel Rattenleber und Dünndarm 

Verwendete Abkürzungen

XOD

Xanthinoxydase

GAPDH

Glycerinaldehyd-3-Phosphat-Dehydrogenase

The role of xanthine oxidase in iron metabolism

Summary

The ferritin-xanthine-oxidase system has been proposed as mechanism for the mobilisation of iron from the liver and intestinal mucosa. Rats were given (orally and i.p.) allopurinol, a potent inhibitor of xanthine oxidase. The activity of xanthine-oxidase (XOD) in the liver and the intestinal mucosa as well as the iron content of the liver were determined:
  1. 1.

    Rats on a low iron diet for 6 weeks developed an iron deficiency anemia and depletion of depot iron in the liver. The XOD activity in liver and small intestine decreased significantly.

     
  2. 2.

    Allopurinol inhibits the XOD activity mainly in the liver, the XOD activity in the mucosa of the small intestine is unchanged. Although the iron absorption remains unchanged under allopurinol application, the nonhemin-iron accumulated significantly simultaneously in the liver. The results indicate that the iron metabolism is not regulated by the activity of the XOD.

     
  3. 3.

    The activity of the glycerinaldehydphosphat-dehydrogenase (GAPDH) in the liver paralleled the decrease of the XOD under allopurinol administration. Although the allopurinol-induced decrease of the XOD in the liver correlates with an increased iron deposition, the simultaneously decreased GAPDH activity indicates an unspecific effect of allopurinol on iron metabolism in the liver.

     

Key-words

Xanthine oxidase Allopurinol Iron metabolism Rat liver and intestinal mucosa 
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Copyright information

© Springer-Verlag 1971

Authors and Affiliations

  • G. Strohmeyer
    • 1
  • O. Chearanai
    • 1
    • 2
  • H. Goebell
    • 1
  1. 1.Medizinische Universitätsklinik Marburg a. d. LahnDeutschland
  2. 2.Siriraj-UniversitätshospitalBangkokThailand

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