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Der Einfluß von Methylprednisolon auf das Renin-Angiotensin-System im Endotoxin-Schock und während orthostatischer Belastung beim Kaninchen

  • H. W. Seyberth
  • D. Haack
  • L. Miksche
Article
  • 12 Downloads

Zusammenfassung

Sowohl im Endotoxinschock als auch unter orthostatischer Belastung kam es beim wachen Kaninchen zu einem deutlichen Anstieg der Plasma-Renin-Aktivität. Unter hohen Glucocorticoid-Dosen, die 5 min nach Endotoxin verabreicht wurden, normalisierte sich die Plasma-Renin-Aktivität innerhalb von 4 Std. Unter orthostatischer Belastung war mit der gleichen Glucocorticoid-Dosis keine statistisch gesicherte Wirkung auf den Anstieg der Plasma-Renin-Aktivität erreichbar.

Schlüsselwörter

Renin Endotoxin-Schock Orthostase Glucocorticoid 

The influence of methylprednisolon on the renin-angiotensin-system in endotoxin and orthostatic shock in the rabbit

Summary

The plasma-renin-activity was significantly increased in endotoxin as well as orthostatic shock in unanaesthesized rabbits. High doses of glucocorticoids, administered 5 min after the endotoxin-injection, normalized the plasma-renin-activity after 4 hrs. In orthostatic shock the same doses of glucocorticoids had only a mild effect on the increase of plasma-renin-activity, which was not of statistical significance.

Key-words

Renin Endotoxin Shock Orthostatic Shock Glucocorticoids 

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Copyright information

© Springer-Verlag 1971

Authors and Affiliations

  • H. W. Seyberth
    • 1
  • D. Haack
    • 1
  • L. Miksche
    • 1
  1. 1.Pharmakologisches Institut der Universität HeidelbergDeutschland

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