Neuroimmunology in multiple sclerosis

  • Cazzullo C. L. 
  • Caputo D. 
  • Parravicini C. 
Original Articles
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Abstract

A review of latest immunological interpretations regarding the pathogenesis of Multiple the Sclerosis.

Data on a new immunoenzymatic method for the identification of blood lymphocyte populations are presented together with preliminary results relating to an immunogenetic correlation between primary affective disorders and Multiple Sclerosis.

Key-words

neuroimmunology multiple sclerosis 

Sommario

Gli autori riferiscono sulle ultime interpretazioni immunologiche riguardanti la patogenesi della sclerosi multipla. Vengono presentati i dati concernenti un nouvo metodo immunoenzimatico per l'identificazione delle popolazioni linfocitarie.

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References

  1. [1]
    Weiner H.L., Hanser S.L.:Neuroimmunology I; immunoregulation in neurological diseases. Ann. Neurol. 11, 437, 1982.CrossRefPubMedGoogle Scholar
  2. [2]
    Witaker J.N., Lisak R.P., Bashir R.M., Fitch O.H., Seyer J.M., Krance R., Lawrence J.A., Ch'ieh L.T., O'Sullivan P.:Immunoreactive myelin basic protein in the cerebral spinal fluid in neurological disorders. Ann. Neurol. 7, 58, 1980CrossRefPubMedGoogle Scholar
  3. [3]
    Waksman B.H.:Current trends in M. S. research Immunology Today 2, 87, 1981CrossRefGoogle Scholar
  4. [4]
    Caputo D.,Ferrante P.Indagini virologiche nella S.M. Atti XXII Congresso Naz. SIN — Scalea 5–7/XI, 1981 Crippa e Berger Ed. pag. 189.Google Scholar
  5. [5]
    Ferrante P.:Il ruolo degli Studi virologici nella comprensione della eziologia della S.M. Proposte Atti HI Convegno di Neuroepidemiologia — Milano 1982.Google Scholar
  6. [6]
    Bergamini F.:Slow virus e malattie croniche del SNC. Boll. Ist. Sieroter. Milano. 56, 589–596, 1977Google Scholar
  7. [7]
    Choppin P.W., Richardson C.D., Merz D.C., Hall W.W., Sheid A.:The functions and inhibition of the membrane glycoproteins of paramyxoviruses and myxoviruses and the role of the measles virus M protein in SSPE. J. Infect. Dis. 143, 352, 1981.PubMedGoogle Scholar
  8. [8]
    Martin J.R.,Herpes simplex virus type 1 and 2 and M.S. Lancet ii, 777, 1981.CrossRefGoogle Scholar
  9. [9]
    Warner H.B., Carp R.I.:M.S. and Epstein-Barr virus. Lancet ii, 1290, 1981CrossRefGoogle Scholar
  10. [10]
    Delmotte P.:Resultats comparatifs de l'électrophorèse en agar et de l'examen par électrofocalization des gammaglobulines du liquide céphalorachidien. Acta Neurol. Belg. 72, 226, 1972.PubMedGoogle Scholar
  11. [11]
    Delmotte P., Gonsette R.:Biochemical findings in M.S. IV Isoelectric focusing of the CSF gammaglobulins in M.S. and OND. J. Neurol. 216, 27, 1977.CrossRefPubMedGoogle Scholar
  12. [12]
    Kyellin K.G., Vestenberg O.:Isoelectric focusing of CSF in neurological diseases. J. Neurol. Sci. 23, 199, 1974.CrossRefPubMedGoogle Scholar
  13. [13]
    Procaccia S., Nickerson C.J., Caputo D., Cazzullo C.L., Zanussi C.:Cerebrospinal fluid immunoglobulins G in patients with M.S. The Menarin Series on Immunopathology II Symp. Milan June 14–16 1978. Eds Schwabe e Co. LTD - Basel 77, 231, 1979Google Scholar
  14. [14]
    Vandvik B., Degre M.:Measles virus antibodies in serum and cerebrospinal fluid in patients with M.S. and other neurological disorders with special reference to measles antibody synthesis within the central nervous system. J. Neurol. Sci. 24, 201, 1975CrossRefPubMedGoogle Scholar
  15. [15]
    Cook S.D.,Dowling P.C.:M. S. and viruses: an overview. Neurology 30.2.80 1980Google Scholar
  16. [16]
    Procaccia S. Caputo D., Ferrante P. et al. Circulating and viral antibodies in MS.New Trends in M.S. research Ed. by Cazzullo C.L., Caputo D., Ghezzi A., Masson (MI), 1983 (in Press)Google Scholar
  17. [17]
    Over J.F., Arnason B.G.W., Wray S.M., Wistler J.P.:A study of bands T cells in M.S. Neurology 25, 444, 1975PubMedGoogle Scholar
  18. [18]
    Antel J.P., Richman D.P., Medof M.E., Arnason B.G.W.:Lymphocyte function and the role of regulator cells in M.S. Neurology 28, Suppl. 106, 1978PubMedGoogle Scholar
  19. [19]
    Bach M.A., Phan-Dinh-Tuy F., Tonnier S., Chatenoud L., Bach J.F., Martin C., Deges J.D.:Deficit of Suppressor T cells in active M.S. Lancet ii, 1221, 1980CrossRefGoogle Scholar
  20. [20]
    Huddlestone J.R., Oldstone M.B.A.:T suppressor lymphocytes fluctuate in parallel with changes in the clinical cause of patients with M.S.I. J. Immunol. 123, 1615, 1979PubMedGoogle Scholar
  21. [21]
    Reinhertz E.L., Weiner H.L., Hansen S.L., Cochen J.A., Distaso J.A., Schlossman S.F.:Loss of suppressor T cells in active M.S. N. Engl. J. Med. 3, 125, 1980.Google Scholar
  22. [22]
    Bloom B.R.:Immunological changes in M.S. Nature 287, 275, 1980CrossRefPubMedGoogle Scholar
  23. [23]
    Merrill J.E., Biberfled G., Landia S. Siden A., Norrby E.:Identification of three FcR-positive T cell subsets (T, T mu and T gamma mu) in the CSF of M.S. patients. Clin. Exp. Immunol. 42 (2) 345, 1980PubMedGoogle Scholar
  24. [24]
    Ortiz-Ortiz G., Nakamura F., Weigle A.:T-cell requirement for Experimental Allergic Encephalomyelitis induction in the rat. J. Immunol. 117, 575–579, 1976Google Scholar
  25. [25]
    Whitacre C.C., Paterson P.Y.:Experimental Allergic Encephalomyelitis supernatant transfer activity in Lewis Rats: immunobiologic and initial biochemical properties J. Immunol. 124, 1784–1787, 1980PubMedGoogle Scholar
  26. [26]
    Whitacre C.C., Paterson P.Y., Day A.D., Bornstein M.B.:Experimental Allergic Encephalomyelitis Supernate Transfer Activity in Lewis Rats: undiminished activity of Ig-depleted supernates and evidence for xenogeneic restriction. Cell. Immunol. 52, 78–84, 1981.Google Scholar
  27. [27]
    Traugott U., Raine C.S.:Experimental Allergic Encephalomyelitis in inbred guinea pigs: correlation of decrease in early-T-cells with clinical signs in suppressed and unsuppressed animals. Cell. Immunol. 34, 146–155, 1977CrossRefPubMedGoogle Scholar
  28. [28]
    Traugott U., Stone S.H., Raine C.S.:Chronic relapsing experimental allergic encephalomyelitis. Correlation of lymphocytes circulating fluctuations with disease activity in suppressed and unsuppressed animals. J. Neurol. Sci. 41, 17–19, 1979CrossRefPubMedGoogle Scholar
  29. [29]
    Catovsky D.:T-cell origin of acid-phopshatasepositive lymphoblasts. Lancet 2, 327–328, 1975.CrossRefPubMedGoogle Scholar
  30. [30]
    Catovky D., Enno A.:Morphological and cytochemical identification of lymphoid cell. Lymphology 10, 77–84, 1977.PubMedGoogle Scholar
  31. [31]
    Li C.Y., Lam K.W., Yam L.T.:Esterase in human leukocytes. J. Histochem. Cytochem. 21, 12, 1973.Google Scholar
  32. [32]
    Tamaoky N., Essner E.:Distribution of acid phosphatase, beta-glucuronidase and N-acetylbeta-glucosaminidase activities in lymphocytes of lymphatic tissues of man and rodents. J. Histochem. Cytochem. 17, 238–243, 1969.PubMedGoogle Scholar
  33. [33]
    Knowles D.M., Holck S.:Tissue localization of T-lymphocytes by the histochemical demonstration of acid alpha-acetate esterase. Lab. Inv. 39, 70–76, 1978Google Scholar
  34. [34]
    Knowles D.M., Halper J.P., Machin G.A., Sherman W.:Acid alpha-naphthyl-acetate esterase activity in human neoplastic lymphoid cells: usefulness as a T-cell marker. Am. J. Pathol. 96, 257–278, 1979.PubMedGoogle Scholar
  35. [35]
    Pinkus G.S., Hargreaves H.M., McLedd J.A., Nadler M.L., Rosenthal D.S., Said J.W.:Alpha-naphthyl acetate esterase activity: a cytochemical marker for T-lymphocytes. Am. Ass. of Pathologist 97, 18–41, 1979.Google Scholar
  36. [36]
    Pangalis G.A., Waldman S.R., Rappaport H.:Cytochemical findings in human non neoplastic blood and tonsillar B and T lymphocytes. Am. J. Clin. Pathol. 69, 314–318, 1978.PubMedGoogle Scholar
  37. [37]
    Yang K., Bearman R.M., Gerassimos A., Pangalis, Zelman R.J., Rappaport H.:Acid phosphatase and alpha-naphthyl acetate esterase in neoplastic and non-neoplastic lymhocytes. Am. J. Clin. Pathol. 78, 141–149, 1982.PubMedGoogle Scholar
  38. [38]
    Grossi C.E., Webb S.R., Zicca A., Lydyard P.M., Moretta L., Mingari M., Copper M.D.:Morphological and histochemical analyses of two human T-Cell sub-populations bearing receptors for IgM or IgG. J. Exp. Med. 147, 1405–1417, 1978.CrossRefPubMedGoogle Scholar
  39. [39]
    Manconi P.E., Maposu M.G., Paghi L., Correale G., Zaccheo D.:Alpha-napthyl acetateesterase activity in human lymphocytes distribution in lymphocyte subpopulations and in mitogenactivated cells. Scand. J. Immunol. 9, 99–104, 1979.PubMedGoogle Scholar
  40. [40]
    Bouet J.C., Valensi F., Daniel M.T., Flandrin G., Preud'homme J.L., Seligmann M.:Immunological classification of ALL: evaluation of its clinical significance in a hundred patients. Br. J. Haematol. 33, 319–328, 1976.PubMedGoogle Scholar
  41. [41]
    Ranky A.:Non specific esterase activity in human lymphocytes: histochemical characterization and demonstration among major lymphocytes subclasses. Clin. Immun. Immunopathol. 10, 47–58, 1978.CrossRefGoogle Scholar
  42. [42]
    Cazzullo C.L., Smeraldi E.:HL-A antigens and multiple sclerosis. Lancet ii, 429, 1972.CrossRefGoogle Scholar
  43. [43]
    Zibetti A., Cazzullo C.L., Smeraldi E., Scor-za-Smeraldi R.:HLA typing on Italian M.S. population. Boll. Ist. Sieroter. Milan. 56, 6, 583, 1977.Google Scholar
  44. [44]
    Coming D.E.:PC1 Duarte a common polymorphism of a human brain protein and its relationship to depressive disease and M.S.. Nature 277, 28, 1979.CrossRefPubMedGoogle Scholar
  45. [45]
    Cazzullo C.L.,Smeraldi E.,Gasparini M.,Caputo D.:Preliminary correlation between primary affective disorders and multiple sclerosis. New Trends in M.S. research. Edited by Cazzullo C.L., Caputo D., Ghezzi A. - Masson Italia (MI) — In Press.Google Scholar
  46. [46]
    Gasser D.L., Newlin C.M., Palm J., Gonatas N.K.:Genetic control of susceptibility to experimental allergic encephalomyelitis in rats. Science 181, 872, 1973.PubMedGoogle Scholar

Copyright information

© Masson Italia Editori S.p.A. 1983

Authors and Affiliations

  • Cazzullo C. L. 
    • 1
  • Caputo D. 
    • 1
  • Parravicini C. 
    • 2
  1. 1.Centro Studi Sclerosi Multipla dell'UniversitáMilano
  2. 2.Servizio di Anatomia Patologica dell'Ospedale L. SaccoMilano

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