Isolierte Perfusion der Hundeniere in situ vor und während Mannitdiurese

  • K. Messmer
  • L. Rosenthal
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Zusammenfassung

Bei 25 Hunden wurde die Diurese der isoliert in situ perfundierten Niere vor und während Mannitoldauerinfusion kontrolliert.
  1. 1.

    Die isolierte Perfusion in situ selbst führte zu einem geringen GFRAbfall und zu einem signifikanten Abfall von U/Posm, U/PNa und U/PK.

     
  2. 2.

    Mannit bewirkt an der perfundierten Niere eine starke Diurese, deren Ausmaß von der Einstellung des Perfusionsvolumens abhängt und — bei konstantem Perfusionsvolumen und kontinuierlicher Mannitinfusion — während 30 min kontinuierlich zunimmt.

     
  3. 3.

    Die Ergebnisse lassen in Übereinstimmung mit den Literaturbefunden den Schluß zu, daß die Mannitdiurese weitgehend von der intrarenalen Umverteilung der Durchblutung mit relativer Begünstigung der Nierenmarkdurchblutung abhängt.

     

Summary

In 25 dogs diuresis was investigated in the isolated in situ perfused kidney before and during intravenous infusion of mannitol.
  1. 1.

    The isolated in situ perfusion was followed by a slight decrease of GFR and a significant decrease of U/P ratios from osmolarity, sodium and potassium.

     
  2. 2.

    In the perfused kidney the application of mannit causes a marked diuresis. The increase in urinary excretion was dependent to the quantity of the perfusion volume. A perfusion with constant volume during 30 min. and continuous mannit infusion resulted in a steady increase of diuresis.

     
  3. 3.

    In accordance with findings by other investigators these results lead to the conclusion that the mannit-induced diuresis to a great extend is related of the intrarenal redistribution of blood supply particularly that of medullary flow.

     
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Copyright information

© Springer-Verlag 1966

Authors and Affiliations

  • K. Messmer
    • 1
  • L. Rosenthal
    • 1
  1. 1.Abteilung für experimentelle ChirurgieChirurgische Universitätsklinik MünchenDeutschland

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