Clostridium difficile colitis associated with the use of antineoplastic agents
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Eight patients are presented in whom treatment with antineoplastic agents, in particular the folic acid antagonist methotrexate, precipitatedClostridium difficile-related diarrhoea and pseudomembranous colitis. The clinical presentation of these patients was identical to that encountered in patients developing antibiotic associated diarrhoea and colitis.Clostridium difficile-related diarrhoea and colitis should be suspected in any patient developing diarrhoea during the course of antineoplastic chemotherapy or within three weeks of its cessation. This complication is effectively treated with oral vancomycin.
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