Endocapsular lavage with photofrin II as a photodynamic therapy for lens epithelial proliferation
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The most common and visually significant complication of both extracapsular and endocapsular cataract extractions is the formation of a secondary cataract because of the proliferation of retained lens epithelial cells. The intraocular distribution of Photofrin II uptake after endocapsular lensectomy and lavage has been quantified to evaluate the feasibility of photodynamic therapy to prevent proliferation.
Intraocular distribution was determined by measuring the fluorescence decay curves in sections of eyes using a microspectrofluorometer with high spatial and temporal resolution. An equal affinity for lens epithelium, corneal endothelium, iris and ciliary body was noted. No significant uptake in the retina was detected. Evaluation of photodynamic therapy to prevent lens epithelial proliferation will require specific localization of the drug to lens epithelium.
Key wordsHaematoporphyrin derivative Secondary cataract Phaco-Ersatz Endocapsular surgery Time-resolved fluorescence microscopy
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