Clinical Rheumatology

, Volume 4, Issue 1, pp 76–82 | Cite as

Clinical study of Thai patients with ankylosing spondylitis

  • U. Deesomchok
  • T. Tumrasvin
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Summary

Sixty-one Thai patients with ankylosing spondylitis (AS), diagnosed in accordance with Rome and New York criteria for AS, were studied. The cases includes idiopathic AS (46 cases), Reiter's syndrome AS (8 cases) and psoriatic spondylitis (7 cases). The vast majority of patients were male (Male∶Female = 11.2∶1), and in over three-fourths the age of onset was between 10 and 39. Low back pain and peripheral arthritis as the initial manifestations were observed in 78.68 and 55.73% of patients respectively. Peripheral arthritis was evident during the course of illness in 72.13 % of cases, oligoarticular arthritis being predominant (68.97%). Heel pain, tendonitis and plantar pain were noted in 19.67, 4.92 and 3.28% respectively. Most patients had lumbosacral and thoracic spine involvements, and only 49.18% showed involvement of the cervical spine. Bilateral sacroiliitis was noted in 98.36%. Uveitis was evident in 11.47% while evidence of aortic insufficiency was noted in 3.28%. An association with HLA-B27 was encountered in 91.07% of all cases. In general, the clinical features of AS in Thai patients are similar to those reported elsewhere, but an association with inflammatory bowel disease and Behcet's disease are notably absent.

Key words

Ankylosing Spondylitis HLA-B27 
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References

  1. 1.
    Graham, W., Uchida, I.A. Hereditary in ankylosing spondylitis. Ann Rheum Dis, 1957, 16, 334.PubMedGoogle Scholar
  2. 2.
    Emery, A.E., Lawrence, J.S. Genetics of ankylosing spondylitis. J Med Genet, 1967, 4, 239.PubMedGoogle Scholar
  3. 3.
    Brewerton, D.A., James, D.C.O. The histocompatibility antigen (HLA 27) and diseases. Semin Arthritis Rheum, 1975, 4, 191.PubMedGoogle Scholar
  4. 4.
    Sonozaki, H., Seki, H., Chang, S., Okuyama, M., Juju, T. Human lymphocyte antigen, HLA 27 in Japanese patients with ankylosing spondylitis. Tissue antigens, 1975, 5, 131.PubMedGoogle Scholar
  5. 5.
    Cohen, I.M., Mittal, K.K., Schamid, F.R., Regers, L.F., Cohen, K.L. Increased risk for spondylitis stigmata in apparently healthy HLA-W27 men. Ann Int Med, 1976, 84, 1.PubMedGoogle Scholar
  6. 6.
    Calin, A. The relationship between genetics and environment in the pathogenesis of rheumatic disease (Medical progress). West J Med, 1979, 131, 205.Google Scholar
  7. 7.
    Wrigh, V. Seronegative polyarthritis: A unified concept. Arthritis Rheum, 1978, 21, 619.PubMedGoogle Scholar
  8. 8.
    Wright, V. A unifying concept for the spondyloarthropathy. Clin Orthop, 1979, 143, 8.PubMedGoogle Scholar
  9. 9.
    Polley, H.F., Slocumb, C.H. Rheumatoid spondylitis: A study of 1,035 cases. Ann Int Med, 1947, 26, 240.Google Scholar
  10. 10.
    Wilkinson, M., Bywaters, G.L. Clinical features and course of ankylosing spondylitis. Ann Rheum Dis, 1958 17, 209.PubMedGoogle Scholar
  11. 11.
    Gofton, J.P., Robinson, H.S., Truman, G.E. Ankylosing spondylitis in a Canadian Indian population. Ann Rheum DFis, 1966, 25, 525.Google Scholar
  12. 12.
    Schaller, J., Bitnum, S., Wedwood, R.J. Ankylosing spondylitis with childhood onset. J Pediatric, 1969, 74, 505.Google Scholar
  13. 13.
    Ladd, J.R., Cassidy, J.T., Martel, W. Juvenile ankylosing spondylitis Arthritis Rheum, 1971, 14, 579.PubMedGoogle Scholar
  14. 14.
    Ball, J. Enthesopathy of rheumatoid and ankylosing spondylitis. Ann Rheum Dis, 1971, 30, 213.PubMedGoogle Scholar
  15. 15.
    Cawley, M.I.D., Chalmers, T.M., Kellgran, J.H., Ball, J. Destructive lesion of vertebrae bodies in ankylosing spondylitis. Ann Rheum Dis, 1972, 31, 345.PubMedGoogle Scholar
  16. 16.
    Mc Bryde, A.M., Mc Collum, D.E. Ankylosing spondylitis in women: The disease and its prognosis. North Carolina Med J, 1973 34, 34.Google Scholar
  17. 17.
    Veys, E.M., Van Laere, M. Serum IgG, IgM and IgA levels in ankylosing spondylitis. Ann Rheum Dis, 1973, 32, 493.PubMedGoogle Scholar
  18. 18.
    Sturrock, R.D., Barrett, A.J., Versy, J., et al. Raised level of complement in activation product in ankylosing spondylitis. J Rheumatol, 1974, 14, 428.Google Scholar
  19. 19.
    Kinsella, T.D., Espinoza, L., Vasey, F.B. Complement and immunoglobulin levels in sporadic and familial ankylosing spondylitis. J Rheumatol, 1975, 2, 308.PubMedGoogle Scholar
  20. 20.
    Bywaters, E.G.L. Ankylosing spondylitis in childhood. Clin Rheum Dis, 1976, 2, 387.Google Scholar
  21. 21.
    Corrigal, V., Panayi, G.S., Unger, A., Poston, R.N., Williams, B.D. Detection of immune complexes in serum of patients with ankylosing spondylitis. Ann Rheum Dis, 1978, 37, 159.PubMedGoogle Scholar
  22. 22.
    Cawdell, D.R., Cowling, P., Ebringer, A. Sequential studies in ankylosing spondylitis. Association of Klebsiella pneumoniae with action disease. Ann Rheum Dis, 1978, 37, 146.PubMedGoogle Scholar
  23. 23.
    Benneth, P.H., Burch, T.A. Population studies of the rheumatic diseases. Amsterdam, Ecepta Medical Foundation, 1968, 305.Google Scholar
  24. 24.
    Terasaki, P.L., Mc Clelland, J.D. Microdroplet assay of human serum cytotoxin. Nature (London), 1964, 204, 998.Google Scholar
  25. 25.
    Good, A.E. Reiter's disease: A review with special attention to cardiovascular and neurologic sequelae. Semin Arthritis Rheum, 1974, 3, 253.PubMedGoogle Scholar
  26. 26.
    Moll, J.M.H., Wright, V. Psoriatic arthritis. Semin Arthritis Rheum, 1973, 3, 55.PubMedGoogle Scholar
  27. 27.
    Moll, J.M.H., Haslock, L, Macrae, I.F., Wright, V. Association between ankylosing spondylitis, psoriatic arthritis, Reiter's disease, The intestinal arthropathies and Behcet's syndrome. Medicine, 1974, 53, 343.PubMedGoogle Scholar
  28. 28.
    Oates, J.K., Young, A.C. Sacroiliitis in Reiter's disease. Br Med J, 1959, 1, 1013.Google Scholar
  29. 29.
    Mason, R.M., Murray, R.S., Oates, J.K., Young, A.C. A comparative radiological study of Reiter's disease, rheumatoid arthritis and ankylosing spondylitis J Bone joint Surg, 1959, 413, 137.Google Scholar
  30. 30.
    Kelly, J.J., Weisiger, B.B. The arthritis of Whipple's disease. Arthritis Rheum, 1963, 6, 615.Google Scholar
  31. 31.
    Barnes, C.G. In discussion following Behcet's syndrome with arthritis by Mason, R.M., Barnes, C.G. Ann Rheum Dis, 1969, 28, 95.Google Scholar
  32. 32.
    Mc Ewen, C., Ditata, D., Lingg, C., Porini, A., Good, A., Ranpin, T. Ankylosing spondylitis and spondylitis accompanying ulceration colitis, regional enteritis, psoriasis and Reiter's disease. Arthritis Rheum, 1971, 14, 291.PubMedGoogle Scholar
  33. 33.
    Zizic, T.M., Steven, M.B. The arthropathy of Behcet's disease. Johns Hopkins Med J, 1975, 136, 243.PubMedGoogle Scholar
  34. 34.
    Greenstein, A.J., Janonrtz, H.D., Sacher, B.D. The extra-intestinal complication of Crohn's disease and ulceration colitis: A study of 700 patients. Medicine, 1976, 55, 401.PubMedGoogle Scholar
  35. 35.
    Wright, V., Moll, J.M.H. Seronegative polyarthritis. Amsterdam, North-Holland publishing company, 1976, 271–328.Google Scholar
  36. 36.
    Lambert, J.R., Wright, V. Psoriatic spondylitis. A clinical and radiological description of spine in psoriatic arthritis. Q J Med, 1977, 46, 411.PubMedGoogle Scholar
  37. 37.
    Decker-Saeye, B.J., Manwissen, S.G.M., Van der Berg Losnen, E.M., De Haas, W.H.D., Agenant, D., Tytgat, G.N.J. II. Prevalence of peripheral arthritis, suffering from inflammatory bowel disease. Ann Rheum Dis, 1978, 37, 33.PubMedGoogle Scholar
  38. 38.
    Viranuvatti, V., Damrongsak, C., Hitanant, S., Tuchinda, S., Asranich, C., Limwongse, K., Chainuvat, T. Ulcerative colitis in Thailand. J Med Assoc Thai, 1975, 58, 312.PubMedGoogle Scholar
  39. 39.
    Mitarnum, W., Wacharasin, R., Kapilakarn, S. Chronic ileitis possible Crohn's disease: A report of 11 cases in Southern Thailand. J Med Assoc Thai, 1982, 65, 372.PubMedGoogle Scholar
  40. 40.
    Ogryzlo, M.A., Rosen, P.S. Ankylosing spondylitis (Marie-Strumpell). Postgrad Med, 1969, 182.Google Scholar
  41. 41.
    Resnick, D. Pattern of peripheral joint diseases in ankylosing spondylitis. Radiology, 1974, 110, 523.PubMedGoogle Scholar
  42. 42.
    Blumberg, B., Ragan, C. The natural history of rheumatoid spondylitis. Medicine, 1956, 35, 1.PubMedGoogle Scholar
  43. 43.
    Graham, D.C., Smythe, H.A. The carditis and aortitis of ankylosing spondylitis. Bull Rheum Dis, 1958, 9, 171.PubMedGoogle Scholar
  44. 44.
    Kendall, M.J., Lawrence, D.S., Shuttleworth, G.R., Whitfield, A.G.W. Hematology and biochemistry of ankylosing spondylitis. Br Med J, 1973, 2, 235.PubMedGoogle Scholar
  45. 45.
    Schlosstein, L., Terrasaki, P.L., Bluestone, R., Pearson, C.M. High association of an HLA antigen, W27, with ankylosing spondylitis. N Eng J Med, 1973, 288, 704.Google Scholar
  46. 46.
    Brewerston, D.A., Hart, F.D., Nicholls, A., Cappery, M., James, D.C.O., Sturrock, R.D. Ankylosing spondylitis and HLA 27. Lancet, 1973, 1, 904.PubMedGoogle Scholar
  47. 47.
    Deesomchok, U., Tumrasvin, T., Bejraputra, O. Incidence of HLA-B27 in Thai patients with arthritis. J Med Assoc Thai, 1983, 66, 600.PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • U. Deesomchok
    • 1
  • T. Tumrasvin
    • 1
  1. 1.Division of Rheumatology, Department of Medicine, Faculty of Medicine, Chulalongkorn HospitalChulalongkorn UniversityBangkokThailand

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