Clinical Rheumatology

, Volume 2, Issue 1, pp 53–56 | Cite as

Joint fluid leukocytosis of patient with rheumatoid arthritis computer analysis of possible explanative factors

  • B. Norberg
  • A. Bjelle
  • S. Eriksson


The relationship between joint fluid leukocytosis and some clinical and laboratory parameters (disease duration, ESR, maximal titres of rheumatoid factor and of antinuclear factors, blood leukocytosis and sex) was studied in 27 consecutive patients with seropositive rheumatoid arthritis. The concentration of leukocytes was significantly higher in the synovial fluid than in peripheral blood. Variations of joint fluid leukocytosis could, however, not be explained by disease duration, actual ESR, maximal rheumatoid factor or antinuclear factor titres, concentration of blood leukocytes, or sex. It is suggested that a possible correlation between joint fluid leukocytosis and the listed parameters of rheumatoid arthritis may be too complex for analysis by a linear multiple regression model in samples of the present size.

Key words

Rheumatoid Arthritis Synovial Fluid Leukocytosis Blood Leukocytosis 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Hollander, J.L., McCarty, D.J., Astorga, G., Castro-Murillo, E. Studies on the pathogenesis of rheumatoid joint inflammation. I. The ”R.A. cell” and a working hypothesis. Ann. Intern. Med. 1965, 62, 271–280.PubMedGoogle Scholar
  2. 2.
    Ropes, M.W., Bennet G.A., Cobb, S., Jacox, R., Jessor, R.A. Diagnostic criteria for rheumatoid arthritis, 1958 revision. Ann. Rheum. Dis. 1959, 18, 49–53.PubMedCrossRefGoogle Scholar
  3. 3.
    Siegel, S. Nonparametric statistics for the behavioral sciences. New York, McGraw-Hill, 1956.Google Scholar
  4. 4.
    Snedecor, G.W., Cochran, W.G. Statistical methods. Ames: Iowa State University Press, 1967.Google Scholar
  5. 5.
    Bjelle, A., Norberg, B., Sjögren, G. The cytology of joint exudates in rheumatoid arthritis. Morphology and preparation techniques. Scand. J. Rheumatol. 1982, 11, 124–128.PubMedCrossRefGoogle Scholar
  6. 6.
    Bäck, O., Bandmann, U., Norberg, B., Söderström, U.-B. Direct chemotaxis and leucocyteinduced chemotaxis of polymorphonuclear leucocytes. Significance of complement, incubation time and chemotactic parameters in filter chamber assays. Scand. J. Haematol. 1978, 20, 108–116.PubMedCrossRefGoogle Scholar
  7. 7.
    Rydgren, L., Simmingsköld, G., Bandmann, U., Norberg, B. The role of cytoplasmic microtubules in polymorphonuclear leukocyte chemotaxis. Evidence for the release hypothesis by means of timelapse analysis of PMN movement relative to dotlike attractants. Exp. Cell Res. 1976, 99, 207–220.CrossRefPubMedGoogle Scholar
  8. 8.
    Rydgren, L., Norberg, B., Svensson, B., Simmingsköld, G. The phagocytosis-associated chemotaxis of human mononuclear leucocytes from peripheral blood is not antitubulin-sensitive. Scand. J. Immunol. 1978, 7, 251–257.PubMedCrossRefGoogle Scholar
  9. 9.
    Simmingsköld, G., Bandmann, U., Norberg, B. Mononuclear leucocyte chemotaxis in Boyden chambers: Inhibition by subantimitotic concentrations of antitubulins. Scand. J. Immunol. 1978, 7, 233–238.PubMedCrossRefGoogle Scholar
  10. 10.
    Söderström, U.-B., Simmingsköld, G., Norberg, B., Bäck, O., Rydgren, L. Analysis of polymorphonuclear leukocytte (PMN) migration by the leading-front technique. Random locomotion and chemotaxis. Exp. Cell Res. 1979, 121, 325–329.CrossRefPubMedGoogle Scholar
  11. 11.
    Bandmann, U., Norberg, B., Simmingsköld, G. Griseofulvin inhibition of polymorphonuclear leucocyte chemotaxis in Boyden chambers. Scand. J. Haematol. 1975, 15, 81–87.PubMedCrossRefGoogle Scholar
  12. 12.
    Nilsson, F., Norberg, B., Frederiksen, B., Eriksson, S. The role of the MA-sensitive leukocyte chemotaxis in rheumatoid arthritis. A randomized double-blind clinical trial of griseofulvin treatment. Scand. J. Rheumatol. 1983, 12, in press.Google Scholar

Copyright information

© Springer-Verlag 1983

Authors and Affiliations

  • B. Norberg
    • 1
  • A. Bjelle
    • 1
    • 2
  • S. Eriksson
    • 1
  1. 1.Department of Internal MedicineUniversity HospitalUmeaSweden
  2. 2.Department of RheumatologyUniversity HospitalUmeaSweden

Personalised recommendations