Clinical Rheumatology

, Volume 9, Issue 4, pp 452–460 | Cite as

Open lung biopsy of patients with rheumatoid arthritis

  • M. Hakala
  • P. Pääkkö
  • E. Huhti
  • M. Tarkka
  • S. Sutinen


In order to shed light on the histological changes occurring in the lungs of patients with rheumatoid arthritis (RA), we scrutinized an open lung biopsy file of 199 patients and selected the patients with RA. The histopathological patterns observed were: pulmonary rheumatoid nodules (4 cases, including one with rheumatoid pneumoconiosis); usual interstitial pneumonia (UIP) (2 cases); desquamative interstitial pneumonia (2 cases); bronchiolitis obliterans with patchy organizing pneumonia (2 cases); follicular brochiolitis (1 case); organizing pneumonia always associated with bronchiolitis (3 cases); granulomatous reaction (3 cases); obliterating vasculitis (3 cases); granulomatous vasculitis (1 case); lymphoid hyperplasia (2 cases); and localized pulmonary fibrosis (1 case). The clinical data and laboratory findings for the histopathological groups overlapped and did not properly predict the anatomical picture. Both patients with UIP died of lung disease. Otherwise the prognosis in the series was good.

Key words

Rheumatoid Nodules Bronchiolitis Pneumoconiosis Rheumatoid factor 


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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • M. Hakala
    • 1
    • 4
  • P. Pääkkö
    • 2
  • E. Huhti
    • 1
  • M. Tarkka
    • 3
  • S. Sutinen
    • 2
    • 5
  1. 1.Department of Internal MedicineUniversity of OuluOulu
  2. 2.Department of PathologyUniversity of OuluOulu
  3. 3.Department of SurgeryUniversity of OuluOulu
  4. 4.Päivärinne HospitalMuhos
  5. 5.Mjölbolsta HospitalMeltolaFinland

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