Zeitschrift für Ernährungswissenschaft

, Volume 28, Issue 2, pp 93–102 | Cite as

Alterations in vitamin A metabolism by polyhalogenated aromatic hydrocarbons

  • M. H. Zile
  • P. A. Bank
  • I. A. Roltsch


Adequate stores and adequate tissue levels of vitamin A are maintained by a balance of tissue demands and dietary intake of the vitamin and are modified by many factors, including xenobiotics. It is well established that exposure to polyhalogenated aromatic hydrocarbons (PHAH) decreases hepatic content of vitamin A. Recent findings indicate that hepatic depletion of vitamin A is accompanied by an increase in serum and renal vitamin A content and enhanced excretion of vitamin A metabolites in urine and feces. Examination of tissue retinoid profiles reveals that PHAH exposure causes the generation of increased amounts of polar retinoids. It is very likely that PHAH affect enzymes crucial for regulation of vitamin A storage as well as enhance activities of specific enzymes in vitamin A metabolic pathway.

Key words

vitamin A status polyhalogenated aromatic hydrocarbons metabolism polar retinoids 


Ausreichende Vitamin-A-Speicher und -Gewebslevel werden durch ein Gleichgewicht von Nachfrage der Gewebe nach Vitamin A und der Vitamin-A-Aufnahme durch die Nahrung aufrechterhalten und durch viele Faktoren beeinflußt.

Es ist hinreichend bekannt, daß polyhalogenierte aromatische Kohlenwasserstoffe (PHAH) die Vitamin-A-Speicher der Leber erniedrigen. Neuere Untersuchungen deuten darauf hin, daß die Erniedrigung der Vitamin-A-Leberspeicher von einem Anstieg des Vitamin-A-Gehaltes in Serum und Niere sowie von einer erhöhten Abgabe von Vitamin-A-Metaboliten in Urin und Fäzes begleitet sind. Die Untersuchung der Vitamin-A-Verteilung in verschiedenen Geweben zeigte, daß die Zufuhr von PHAH zu einem verstärkten Auftreten polarer Vitamin-A-Metaboliten führt. Es ist wahrscheinlich, daß die PHAH Enzyme beeinflussen, die entscheidend für die Regulation von Vitamin-A-Speichern sowie der Aktivität von für den Vitamin-A-Stoffwechsel wichtigen Enzymen sind.


Vitamin A-Status polyhalogenierte aromatischeKohlenwasserstoffe Metabolismus polareRetinoide 


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Copyright information

© Dr. Dietrich Steinkopff Verlag 1989

Authors and Affiliations

  • M. H. Zile
    • 1
  • P. A. Bank
    • 1
  • I. A. Roltsch
    • 1
  1. 1.Department of Food Science and Human NutritionMichigan State UniversityEast LansingUSA

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