Clinical Rheumatology

, Volume 8, Issue 2, pp 231–237

Marker antibodies in scleroderma and polymyositis: Clinical associations

  • D. J. De Rooij
  • L. B. A. Van De Putte
  • W. J. Habets
  • W. J. Van Venrooij
Originals

Summary

Sera of 34 patients with progressive systemic sclerosis and of 11 patients with polymyositis/dermatomyositis (PM/DM) were analyzed by the immunoblotting technique for the presence of marker antibodies. The presence of anti-centromere, anti-Topoisomerase-I (anti-Topo-I) and anti-Jo-1 antibodies was found to be highly specific for the CREST syndrome, diffuse scleroderma and PM/DM, respectively, but only of limited sensitivity (78, 44 and 45%, respectively). Anti-Topo-I positive diffuse scleroderma patients had a more severe disease (digital pitting scars and renal insufficency) than anti-Topo-I negative diffuse scleroderma patients. Anti-Jo-1 was associated with interstitial lung disease. Longitudinal studies showed a constant antibody pattern. Our results confirm the clinical usefulness of these marker antibodies.

Key words

Antinuclear Antibodies Immunoblotting Scleroderma Polymyositis 

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Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • D. J. De Rooij
    • 1
  • L. B. A. Van De Putte
    • 1
  • W. J. Habets
    • 2
  • W. J. Van Venrooij
    • 3
  1. 1.Department of RheumatologyNijmegen
  2. 2.Department of RheumatologyUniversity Hospital NijmegenThe Netherlands
  3. 3.Department of BiochemistryUniversity of NijmegenThe Netherlands

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