European Journal of Pediatrics

, Volume 150, Issue 11, pp 782–783

Fatal ureaplasmal pneumonia and sepsis in a newborn infant

  • F. Brus
  • W. M. van Waarde
  • C. Schoots
  • S. Bambang Oetomo
Infectious Diseases

Abstract

Ureaplasma urealyticum was isolated in pure culture from blood tracheal aspirate and lung tissue in a newborn infant, who died of a severe pneumonia within 48h after birth. The clinical course was characterized by persistent pulmonary hypertension of the newborn (PPHN). Post-mortem examination revealed extensive hyaline membrane formation combined with signs of inflammation in both lungs. The clinical and histopathological picture resembled that of early onset group B haemolytic streptococcal pneumonia/sepsis.

Key words

Ureaplasma urealyticum Neonatal pneumonia/sepsis Persistent pulmonary hypertension of the newborr Hyaline membranes 

Abbreviations

GBS

group BStreptococci

PPHN

persistent pulmonary hypertension of the newborn

References

  1. 1.
    Casell GH, Waites KB, Crouse DT, Rudd PT, Canupp KC, Stagno S, Cutter GR (1988) Association of Ureaplasma urealyticum infection of the lower respiratory tract with chronic lung disease and death in very low birth weight infants. Lancet II: 240–245CrossRefGoogle Scholar
  2. 2.
    Cassin S (1980) Role of prostaglandines and thromboxanes in the control of pulmonary circulation in the fetus and new born. Semin Perinatol 4: 101–107PubMedGoogle Scholar
  3. 3.
    Cherry JD (1987) Mycoplasma and Ureaplasma infections. In: Feigin RD, Cherry JD (eds) Textbook of pediatric infectious diesease Vol. II. WB Saunders Company, Philadelphia, pp 1896–1924Google Scholar
  4. 4.
    DeSilva NS, Quinn PA (1986) Endogenous activity of phospholipase A and C in Ureaplasma urealyticum. J Clin Microbiol 23: 354–359PubMedGoogle Scholar
  5. 5.
    Nichols DG, Rogers MC (1987) Adult respiratory syndrome. In: Rogers MC (ed) Textbook of pediatric intensive care, vol II. Williams and Williams, Baltimore, pp 237–271Google Scholar
  6. 6.
    Quinn PA, Gillan JE, markestad T, St John MA, Daneman A, Lie KI, Li HCS, Czegledy-Nagy E, Klein M (1985) Intrauterine infection with Ureaplasma urealyticum as a cause of fatal neonatal pneumonia. Pediatr Infect Dis 4: 538–543PubMedGoogle Scholar
  7. 7.
    Rojas J, Green RS, hellerquist CG, Olegard R, Brigham KL, Stahlman MT (1981) Studies on group B-hemolytic streptococcus: II. Effects of pulmonary hemodynamics and vascular permeability of unanesthetized sheep. Pediatr Res 15: 899–904PubMedGoogle Scholar
  8. 8.
    Runkle B, Goldberg PRN, Streitfield MM, Clark MR, Buron E, Setzer ES, Bomealari E (1984) Cardiovascular changes in group B streptococcal sepsis relationship to prostacyclin and thromboxane A2. Pediatr Res 18: 874–878PubMedGoogle Scholar
  9. 9.
    Shook LA, Pauly TH, Marple SL, Horstman SJ, Tai H-H, Bowdy BD, Gillespie MN (1990) Group B streptococcus promotes oxygen radical-dependent thromboxane accumulation in young piglets. Pediatr Res 27: 349–352PubMedGoogle Scholar
  10. 10.
    Waites KB, Crouse DT, Philips III JB, Canupp KC, Casell GH (1989) Ureaplasmal pneumonia and sepsis associated with persistent pulmonary hypertension of the newborn. Pediatrics 83: 79–85PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • F. Brus
    • 1
  • W. M. van Waarde
    • 1
  • C. Schoots
    • 2
  • S. Bambang Oetomo
    • 1
  1. 1.Departments of Paediatrics, Division of NeonatologyUniversity Hospital GroningenGroningenThe Netherlands
  2. 2.Department of PathologyUniversity Hospital GroningenGroningenThe Netherlands

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