Zeitschrift für Ernährungswissenschaft

, Volume 27, Issue 2, pp 119–125 | Cite as

Vitamin A supply and biochemical development of the rat heart: studies on cellular DNA, RNA and protein

  • Hari S. Sharma
  • U. K. Misra
Original Contributions

Summary

The effect of restricted vitamin A supply to the mother on the biochemical development of the heart in rats has been studied. The vitamin A status of female rats was varied by supplying low, medium and adequate amounts (6, 40, 100 μg retinol/day/kg body weight respectively) of vitamin A during pregnancy and suckling. The vitamin A status of the mother caused an alteration in the developmental pattern of fetal heart in parameters of tissue weight, DNA, RNA and protein contents and the biosynthesis of DNA and protein from [3H]-thymidine and [3H]-leucine respectively. A dose-dependent effect of vitamin A on the metabolism of DNA, RNA and protein was observed in the developing rat hearts. Hence, emphasis should be given to the adequate availability of vitamin A to dams for the normal growth and development of fetal organs.

Key words

vitamin A development offetal heart DNA RNA protein rat 

Zusammenfassung

Die Auswirkung einer beschränkten Vitamin-A-Zufuhr bei trächtigen Ratten auf die biochemische Entwicklung des fetalen Herzens wurde untersucht. Der Vitamin-A-Status der weiblichen Ratten wurde durch Angebot von geringen, mittleren und hohen Mengen an Vitamin A während Trächtigkeit und Säugeperiode verändert (6,40 und 100 μg Retinol/Tag/kg Körpergewicht). Der Vitamin-A-Status der Muttertiere verursachte eine Veränderung in der Entwicklung des fetalen Herzens in bezug auf Gewebegewicht, DNA-, RNA- und Proteingehalt sowie der Biosynthese von DNA und Proteinen aus jeweils [3H]-Thymidin und [3H]-Leucin. In den sich entwickelnden Rattenherzen wurde eine dosisabhängige Wirkung von Vitamin A auf den DNA-, RNA- sowie den Proteinstoffwechsel beobachtet. Eine angemessene Versorgung der Muttertiere mit Vitamin A ist entscheidend für die normale Entwicklung fetaler Organe.

Schlüsselwörter

Vitamin A Entwicklungfetaler Organe DNA RNA Protein Ratte 

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Copyright information

© Dr. Dietrich Steinkopff Verlag 1988

Authors and Affiliations

  • Hari S. Sharma
    • 2
  • U. K. Misra
    • 1
  1. 1.Department of BiochemistryVallabhbhai Patel Chest InstituteDelhiIndia
  2. 2.Abt. Experimentelle KardiologieMax-Planck-Institut für Physiologische und Klinische ForschungBad NauheimWest Germany

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