Zeitschrift für Ernährungswissenschaft

, Volume 19, Issue 1, pp 50–56 | Cite as

Evaluation of the effect of lead exposure on the liver in Egyptian lead tank welders

  • T. H. Mikhail
  • H. A. El-Sawaf
  • Kh. M. Ibrahim
  • R. Awadallah
  • E. A. El-Dessoukey


In a group of Egyptian lead tank welders who were exposed to lead fumes for periods to 22 years the changes in serum lipids and some of the liver function tests which may elucidate the effect of lead on the liver were investigated.

The results revealed increased blood lead level associated with decreased blood haemoglobin and increased urinary excretion of delta amino levulinic acid. However, no clinical abnormalities were recorded in the exposed group of the present work. Thus the increase in serum triglycerides and B-lipoprotein together with the lowering of the phospholipid/cholesterol ratio which were found may indicate premature development of atherosclerosis. Indirect evidence of the beginning of liver fattening was also provided by the increase in serum GOT, GPT, LDH enzymes and decreased albumin/globulin ratio besides the changes in serum lipid values. It is concluded therefore that lead poisoning may have a vascular as well as hepato-toxic action.


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  1. 1.
    Albertini, A., B. D. Prandini, L. Spandrio, E. Bonera, G. Cavalieri: Quad. Sclavo Diagn. (1969).Google Scholar
  2. 2.
    Beanfay, H., E. Van Campenhont, C. De Duve: Biochem. J.73, 617 (1959).CrossRefGoogle Scholar
  3. 3.
    Bloor, W. R.: J. Biol. Chem.63, 1 (1925).Google Scholar
  4. 4.
    Browning, E.: Toxicity of Industrial Metals. Ed. by Butterworth and Co, p. 150, 158. Whiterfriars Press (London) (1961).Google Scholar
  5. 5.
    Cecil Loeb: Text Book of Medicine, 11th edit W. B. Saunders Co. (1963).Google Scholar
  6. 6.
    Cenacchi, G. C., G. Tucci, A. Lodi: Bologna med5, 519 (1959).Google Scholar
  7. 7.
    Duff, G. L., T. P. R. Rayne: J. Exp. Med.92, 299 (1950).CrossRefGoogle Scholar
  8. 8.
    Duff, G. L.: Amer. J. Med.11, 92 (1951).CrossRefGoogle Scholar
  9. 9.
    Folch, J. et al.: J. Biol. Chem.226, 497 (1957).Google Scholar
  10. 10.
    Frank, H., B. Manfred: Z. Ges. Inn. Med.29, 300 (1974).Google Scholar
  11. 11.
    Fumiyo, S., M. Toshimi, Tokushima: J. Expt. Med.24, 105 (1977).Google Scholar
  12. 12.
    Grabecki, J., T. Haduck, H. Urbanoswicz: Arch. Gewerbepath. Gewerbehyg.23, 226 (1967).CrossRefGoogle Scholar
  13. 13.
    Grzybek, H., J. Jonek, D. Kochanka, B. Panz, A. Glanc: Med. Pracy22, 303 (1971).Google Scholar
  14. 14.
    Hanke, J.: Z. Arch. Industr. Hyg. Toxicol.15, 57 (1964).Google Scholar
  15. 15.
    Heinle, R. A., R. I. Levy, D. S. Frederickson, R. Gorbin: Amer. J. Cardiol.24, 178 (1969).CrossRefGoogle Scholar
  16. 16.
    Herenberg, S., J. Nikkanen: Lancet1970/I, 63.CrossRefGoogle Scholar
  17. 17.
    Herenberg, S., J. Nikkanen: Prac. Lek.24, 77 (1972).Google Scholar
  18. 18.
    Kapetonovic, K., S. Radmic, D. Soldatovic: Acta Pharmaceut Jugoslav10, 125 (1960).Google Scholar
  19. 19.
    Keenan, R. G., D. H. Bayers, B. E. Saltzman, F. L. Hyslop: Amer. industr. Hyg. Ass. J.24, 481 (1963).CrossRefGoogle Scholar
  20. 20.
    King, E. J., A. Armstrong: Canad. med. Ass. J.31, 376 (1934).Google Scholar
  21. 21.
    King, E. J., I. D. P. Wootton: Micro-analysis in Medical Biochemistry 4th ed. (London) (1964).Google Scholar
  22. 22.
    Kingsbury, K. J., D. M. Morgan, R. Stovold, C. G. Bett, J. Anderson: Lancet1969/II, 1325.CrossRefGoogle Scholar
  23. 23.
    Konikova, G. S.: Ter. Arh.34, 96 (1962).Google Scholar
  24. 24.
    Kosmider, S.: Arch. Gewerbepath. Gewerbehyg.20, 11 (1953).CrossRefGoogle Scholar
  25. 25.
    Kosmider, S., Z. Petocka: Z. Arbeit-med. Arbeitsschutz,17, 170 (1967).Google Scholar
  26. 26.
    Kruster, L., Z. Zapryanov, R. Dikova, I. Khadzhieva, I. Apostolov, V. Markovska, E. Koen, V. Gulubova: Khig. Zdraveopaz19, 247 (1976) (Bulg.).Google Scholar
  27. 27.
    Minden, H., W. Zegarski, R. Rothe: Arch. Gewerbepath. Gewerbehyg.20, 461 (1964).CrossRefGoogle Scholar
  28. 28.
    Moncrieff, A. A., O. P. Koumides, B. E. Clayton, A. D. Patrick, G. C. Renwick, G. E. Roberts: Arch. Dis. Childhood,39, 1 (1964).CrossRefGoogle Scholar
  29. 29.
    Moore, J. H., D. L. Williams: Brit. J. Nutr.18, 431 (1964).CrossRefGoogle Scholar
  30. 30.
    Morel, J. J., C. Albahary, J. P. Berry, P. Galle, J. Ripault, M. Auriol, H. Desoille, M. Philbert: Arch. Mal. Prof. Med. Trav. Secur. Soc.35, 609 (1974) (Fr.).Google Scholar
  31. 31.
    Morrison, W. R.: Analyt. Biochem.7, 218 (1964).CrossRefGoogle Scholar
  32. 32.
    Prerovska, I.: Proc. Int. Symp. Environ. Health Aspects Lead551, 8 (1972).Google Scholar
  33. 33.
    Reitman, S., S. Frankel: Am. Clin. Path28, 56 (1957).CrossRefGoogle Scholar
  34. 34.
    Rees, R. V. L. Shotlander: Proc. of the Royal Society of London (Biol).157, 517 (1963).CrossRefGoogle Scholar
  35. 35.
    Sahli, H.: In. “Disorders of the Blood“ Ed. by L. E. Whitby, C. J. C. Briton p. 706 (London) 1957.Google Scholar
  36. 36.
    Swahn, B.: Scand J. Clin. Lab. Invest.4, 98 (1952).CrossRefGoogle Scholar
  37. 37.
    Tahani, H. Mikhail, R. Awadallah andE. A. El-Dessoukey: Z. Ernährungswiss.16, 256 (1977).CrossRefGoogle Scholar
  38. 38.
    Timet, D., M. Herak, D. Emanovic, M. Tranger, P. Kaljevic, S. Juzbasic, Z. Majdak, M. Jurkovic: Proc. World Vet. Congr. 20th3, 2363 (1975).Google Scholar
  39. 39.
    Tipton, I. H., H. A. Schroeder, H. M. Perry: Health physics11, 403 (1965).CrossRefGoogle Scholar
  40. 40.
    Urbanska-Bonenberg, L., K. Smigla: Proc. Int. Symp. Environ. Health Aspects, Lead 487 (1972).Google Scholar
  41. 41.
    Van Handel, E. andD. B. Zilversmit: J. Lab. and Clin. Med.50, 152 (1957).Google Scholar
  42. 42.
    Waldman, R. K. andE. K. Borman: Arch. Industr. Health19, 431 (1959).Google Scholar
  43. 43.
    Waldron, H. A.: J. Clin. Path.17, 149 (1964).CrossRefGoogle Scholar
  44. 44.
    Wroblewski, F., P. Ruegsegger andJ. S. LaDue: Science123, 1122 (1956).CrossRefGoogle Scholar
  45. 45.
    Wroblewski, F.: Amer. J. Med.27, 911 (1959).CrossRefGoogle Scholar
  46. 46.
    Ying Han Hsu, Chin-Tang Yu, Ding-An Lou andChung Hua: I Hsüch Tsa Chih43, 886 (1957).Google Scholar

Copyright information

© Dr. Dietrich Steinkopff Verlag 1980

Authors and Affiliations

  • T. H. Mikhail
    • 1
  • H. A. El-Sawaf
    • 1
  • Kh. M. Ibrahim
    • 1
  • R. Awadallah
    • 1
  • E. A. El-Dessoukey
    • 1
  1. 1.National Research CentreDokki, CairoEgypt

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