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Antibodies in milk

  • Esbjörn TelemoEmail author
  • Lars A. Hanson
Article

Abstract

The immaturity of the infant's immune system and the rapid evolution of pathogens has created a demand for the mother to provide ready made specific defence factors to her offspring. This is achieved during the fetal period by transplacental transport of IgG antibodies, and after birth via IgA antibodies in the breast milk. The breast milk also contains a variety of nonspecific defence factors contributing to its antimicrobial effect. Breast feeding has been shown to decrease morbidity in gastroenteritis, septicemia, otitis media, urinary tract infection, encephalitis, pneumonia, and necrotizing enterocolitis. The antibody content in the mother's milk probably contributes not only to the immediate but also to the long term protection of the infant including both resistance to infection and development of immunological tolerance to harmless environmental antigens.

Key words

Antibodies milk IgA 

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References

  1. 1.
    A. J. Guidry and R. H. Miller (1986). Immunoglobulin isotype concentrations in milk as affected by stage of lactation and parity.J. Dairy Sci. 69:1799–1805.PubMedGoogle Scholar
  2. 2.
    L. Å. Hanson and P. Brandtzaeg (1989). The mucosal defence system. In E. R. Stiehm (ed.),Immunological Disorders in Infants and Children, W. B. Saunders, Philadelphia.Google Scholar
  3. 3.
    D. A. Lebman and R. L. Coffman (1988). The effects of IL-4 and IL-5 on the IgA response by murine Peyer's patch B cell subpopulations.J. Immunol. 141:2050–2056.PubMedGoogle Scholar
  4. 4.
    S. Schoenbeck, D. T. McKenzie, and M. F. Kagnoff (1989). Interleukin 5 is a differentiation factor for IgA B cells.Eur. J. Immunol. 19:965–969.PubMedGoogle Scholar
  5. 5.
    J. Mega, J. R. McGhee, and H. Kiyono (1992). Cytokine-and Ig-producing T cells in mucosal effector tissues: analysis of IL-5- and IFN-gamma-producing T cells, T cell receptor expression, and IgA plasma cells from mouse salivary gland-associated tissues.J. Immunol. 148:2030–2039.PubMedGoogle Scholar
  6. 6.
    E. Sonoda, R. Matsumoto, Y. Hitoshi, T. Ishii, M. Sugimoto, S. Araki, A. Tominaga, N. Yamaguchi, and K. Takatsu (1989). Transforming growth factor β induces IgA production and acts additively with interleukin 5 for IgA production.J. Exp. Med. 170:1415–1420.PubMedGoogle Scholar
  7. 7.
    P. van Vlasselaer, J. Punnonen, and J. E. de Vries (1992). Transforming growth factor-beta directs IgA switching in human B cells.J. Immunol. 148:2062–2067.PubMedGoogle Scholar
  8. 8.
    L. Zettel, D. A. Clark, and P. B. Ernst (1992). Transforming growth factor-beta 1 enhances IgG and IgA sheep red blood cell responses.Int. Immunol. 4:975–983.PubMedGoogle Scholar
  9. 9.
    R. Goldblum, S. Ahlstedt, B. Carlsson, L. Hanson, U. Jodal, and G. Lidin-Janson (1975). Antibody-forming cells in human colostrum after oral immunization.Nature 257:797–799.PubMedGoogle Scholar
  10. 10.
    L. Å. Hanson, S. Ahlstedt, C. C. Brinton, B. Carlsson, J. R. Cruz, U. Dahlgren, S. P. Fällström, F. Jalil, O. Porras, Ö. Strannegård, T. Söderström, and B. Wettergren (1983). The enteromammaric link of the secretory IgA system. In P. L. Ogra and D. M. Jacobs (eds.),Regulation of the Immune Response, S. Karger, Basel, pp. 141–153.Google Scholar
  11. 11.
    L. A. Hanson, I. Adlerbert, B. Carlsson, S. B. Castrignano, Z. M. Hahn, U. Dahlgren, F. Jalil, K. Nilsson, and D. Roberton (1989). Immunology of breast-feeding.Beitr Infusionther. 22:10–19.PubMedGoogle Scholar
  12. 12.
    S. Jalkanen, G. Nash, J. De los Toyos, R. MacDermott, and E. Butcher (1989). Human lamina propria lymphocytes bear homing receptors and bind selectively to mucosal lymphoid high endothelium.Eur. J. Immunol. 19:63–68.PubMedGoogle Scholar
  13. 13.
    M. Fishaut, D. Murphy, M. Neifert, K. McIntosh, and P. L. Ogra (1981). Bronchomammary axis in the immune response to respiratory syncytial virus.J. Pediatr. 99:186–191.PubMedGoogle Scholar
  14. 14.
    U. Dahlgren, S. Ahlstedt, and L. Å. Hanson (1987). The localization of the antibody response in milk or bile depends on the nature of the antigen.J. Immunol. 136:1397–1402.Google Scholar
  15. 15.
    P. Weisz-Carrington, M. Roux, M. McWilliams, J. Phillips-Quagliata, and M. Lamm (1978). Hormonal induction of the secretory immune system in the mammary gland.Proc. Natl. Acad. Sci. U.S.A. 75:2928–2932.PubMedGoogle Scholar
  16. 16.
    R. Rosato, H. Jammes, L. Belair, C. Puissant, J. P. Kraehenbuhl, and J. Djiane (1995). Polymeric-Ig receptor gene expression in rabbit mammary gland during pregnancy and lactation: evolution and hormonal regulation.Mol. Cell. Endocrinol. 110:81–87.PubMedGoogle Scholar
  17. 17.
    P. L. Yap, J. McKiernan, C. L. Mirtle, and D. B. McClelland (1981). The development of mammary secretory immunity in the human newborn.Acta Pediatr. Scand. 70:459–465.Google Scholar
  18. 18.
    K. Kim, M. A. Keller, and D. C. Heiner (1992). Immunoglobulin G subclasses in human colostrum, milk and saliva.Acta Pediatr. 81:113–118.Google Scholar
  19. 19.
    U. I. H. Dahlgren, S. Ahlstedt, and L. Å. Hanson (1987). The localization of the antibody response in milk or bile depends on the nature of the antigen.J. Immunol. 138:1397–1402.PubMedGoogle Scholar
  20. 20.
    U. I. Dahlgren, A. E. Wold, L. Å. Hanson, and T. Midtvedt (1990). The secretory antibody response in milk and bile against fimbriae and LPS in rats monoclonised or immunized in the Peyer's patches withEscherichia coli.Immunology 71:295–300.PubMedGoogle Scholar
  21. 21.
    C. M. Mole, P. M. Montagne, M. C. Bene, and G. C. Faure (1992). Sequential assay of human milk immunoglobulins shows a predominance of lambda chains.Lab. Invest. 67:147–151.PubMedGoogle Scholar
  22. 22.
    M. Lamm, P. Weisz-Carrington, M. Roux, M. McWilliams, and J. Phillips-Quagliata (1978). Development of the IgA system in the mammary gland.Adv. Exp. Med. Biol. 107:35–42.PubMedGoogle Scholar
  23. 23.
    P. Brandtzaeg (1985). Role of J chain and secretory component in receptor-mediated glandular transport of immunoglobulins in man.Scand. J. Immunol. 22:111–146.PubMedGoogle Scholar
  24. 24.
    S. Purkayastha, C. Rao, and M. Lamm (1979). Structure of the carbohydrate chain of free secretory component from human milk.J. Biol. Chem. 254:6583–6587.PubMedGoogle Scholar
  25. 25.
    L. Mellander, J. Bjorkander, B. Carlsson, and L. A. Hanson (1986). Secretory antibodies in IgA-deficient and immunosuppressed individuals.J. Clin. Immunol. 6:284–291.PubMedGoogle Scholar
  26. 26.
    M. J. Parmely and L. S. Manning (1983). Cellular determinants of mammary cell-mediated immunity in the rat: kinetics of lymphocyte subset accumulation in the rat mammary gland during pregnancy and lactation.Ann. N. Y. Acad. Sci. 409:517–533.PubMedGoogle Scholar
  27. 27.
    I. Jakobsson, T. Lindberg, B. Benediktson, and G. G. Hansson (1985). Dietary bovine beta-lactoglobulin is transferred to human milk.Acta Pediatr. Scand. 74:342–345.Google Scholar
  28. 28.
    S. Husby, A. Hist, and L. G. Hansen (1991). Characterization of cow milk proteins in human milk: kinetics, size distribution, and possible relation to atopy.Adv. Exp. Med. Biol. 310:405–410.PubMedGoogle Scholar
  29. 29.
    P. J. Kilshaw and A. J. Cant (1985). The passage of maternal dietary antigen into human breast milk.Int. Arch. Allergy Appl. Immunol. 75:8–15.Google Scholar
  30. 30.
    E. Telemo, M. Bailey, B. G. Miller, C. R. Stokes, and F. J. Bourne (1991). Dietary antigen handling by mother and offspring.Scand. J. Immunol. 34:689–696.PubMedGoogle Scholar
  31. 31.
    S. Husby, V. A. Oxelius, and S. E. Svehag (1992). IgG subclass antibodies to dietary antigens in IgA deficiency quantification and correlation with serum IgG subclass levels.Clin. Immunol. Immunopathol. 62:85–90.PubMedGoogle Scholar
  32. 32.
    I. Jakobsson and T. Lindberg (1978). Cow's milk proteins cause infantile colic in breast-fed infants.Lancet 2:437–439.PubMedGoogle Scholar
  33. 33.
    S. Armstrong, A. Coutts, V.-L. M., E. Telemo, C. R. Stokes, and F. J. Bourne (1990). Influence of antigenically primed colostrum on the specific immune response of piglets. In T. T. MacDonaldet al. (eds.),Advances of Mucosal Immunology, Kluver Academic Publisher, Dordrecht, pp. 549–550.Google Scholar
  34. 34.
    L.-Å. Hanson, E. Telemo, U. Wiedermann, A. Dahlman, R. Saalman, S. Ahlstedt, V. Friman, J. Holmgren, C. Czerkinsky, and U. Dahlgren (1993). Sensitization and development of tolerance via the gut.Pediatr. Allergy Immunol. 4 (Suppl. 3):16–20.PubMedGoogle Scholar
  35. 35.
    R. M. Goldblum, L. Å. Hanson, and P. Brandtzaeg (1996).The Mucosal Defence System (4 Ed). W. B. Saunders, Philadelphia.Google Scholar
  36. 36.
    R. G. Feachem and M. A. Koblinsky (1984). Interventions for the control of diarrhoeal diseases among young children: promotion of breast-feeding.Bull WHO 62:271–291.PubMedGoogle Scholar
  37. 37.
    J. N. Walterspiel, A. L. Morrow, M. L. Guerrero, G. M. Ruiz-Palacios, and L. K. Pickering (1994). Secretory anti-Giardia lamblia antibodies in human milk: protective effect against diarrhea.Pediatrics 93:28–31.PubMedGoogle Scholar
  38. 38.
    C. G. Victora, P. G. Smith, J. P. Vaughan, L. C. Nobre, C. Lombardi, A. M. Teixeira, S. M. Fuchs, L. B. Moreira, L. P. Gigante, and F. C. Barros (1987). Evidence for protection by breast-feeding against infant deaths from infectious diseases in Brazil.Lancet 2:319–322.PubMedGoogle Scholar
  39. 39.
    U. M. Saarinen (1982). Prolonged breast feeding as prophylaxis for recurrent otitis media.Acta. Pediatr. Scand. 71:567–571.Google Scholar
  40. 40.
    A. Lucas and T. J. Cole (1990). Breast milk and neonatal necrotising enterocolitis.Lancet 336:1519–1523.PubMedGoogle Scholar
  41. 41.
    P. W. Howie, J. S. Forsyth, S. A. Ogston, A. Clark, and C. du Florey (1990). Protective effect of breast feeding against infection.Brit. Med. J. 300:11–16.PubMedGoogle Scholar
  42. 42.
    J. E. Thomas, S. Austin, A. Dale, P. McClean, M. Harding, W. A. Coward, and L. T. Weaver (1993). Protection by human milk IgA againstHelicobacter pylori infection in infancy [letter].Lancet 342:121.Google Scholar
  43. 43.
    A. Piscane, L. Grazino, G. Zona, G. Granata, H. Dolezalova, M. Cafiero, A. Coppola, B. Scarpellino, M. Ummarino, and G. Mazzarella (1994). Breast feeding and acute lower respiratory infection.Acta. Pediatr. 83:714–718.Google Scholar
  44. 44.
    K. Vudhichamnong, D. M. Walker, and H. C. Ryley (1982). The effect of secretory immunoglobulin A on thein vitro adherence of the yeastCandida albicans to human oral epithelial cells.Arch. Oral Biol. 27:617–621.PubMedGoogle Scholar
  45. 45.
    A. E. Wold, J. Mestecky, M. Tomana, A. Kobata, H. Ohbayashi, T. Endo, and C. Svanborg-Eden (1990). Secretory immunoglobulin A carries oligosaccharide receptors forEscherichia coli type 1 fimbrial lectin.Infect. Immun. 58:3073–3077.PubMedGoogle Scholar
  46. 46.
    A. Wold, C. Motas, C. Svanborg, and J. Mestecky (1994). Lectin receptors on IgA isotypes.Scand. J. Immunol. 39:195–201.PubMedGoogle Scholar
  47. 47.
    P. Michetti, M. J. Mahan, J. M. Slauch, J. J. Mekalanos, and M. R. Neutra (1992). Monoclonal secretory immunoglobulin A protects mice against oral challenge with the invasive pathogenSalmonella typhimurium.Infect. Immun. 60:1786–1792.PubMedGoogle Scholar
  48. 48.
    A. Mizoguchi, T. Mizuochi, and A. Kobata (1982). Structures of the carbohydrate moieties of secretory component purified from human milk.J. Biol. Chem. 257:9612–9621.PubMedGoogle Scholar
  49. 49.
    T. Boren, P. Falk, K. A. Roth, G. Larson, and S. Normark (1993). Attachment ofHelicobacter pylori to human gastric epithelium mediated by blood group antigens.Science 262:1892–1895PubMedGoogle Scholar
  50. 50.
    T. Boren, S. Normark, and P. Falk (1994).Helicobacter pylori: molecular basis for host recognition and bacterial adherence.Trends Microbiol. 2:221–228.PubMedGoogle Scholar
  51. 51.
    M. W. Steward (1971). Resistance of rabbit secretory IgA to proteolysis.Biochim. Biophys. Acta 236:440–449.PubMedGoogle Scholar
  52. 52.
    E. Lindh (1975). Increased risistance of immunoglobulin A dimers to proteolytic degradation after binding of secretory component.J. Immunol. 114:284–286.PubMedGoogle Scholar
  53. 53.
    S. P. Fitzsimmons, M. K. Evans, C. L. Pearce, M. J. Sheridan, R. Wientzen, and M. F. Cole (1994). Immunoglobulin A subclasses in infants' saliva and in saliva and milk from their mothers.J. Pediatr. 124:566–573.PubMedGoogle Scholar
  54. 54.
    M. Hahn-Zoric, F. Fulconis, I. Minoli, G. Moro, B. Carlsson, M. Böttiger, N. Räihä, and L. Å. Hanson (1990). Antibody responses to parenteral and oral vaccines are impaired by conventional and low protein formulas as compared to breast-feeding.Acta. Pediatr. Scand. 79:1137–1142.Google Scholar
  55. 55.
    H. F. Pabst and D. W. Spady (1990). Effect of breast-feeding on antibody response to conjugate vaccine.Lancet 336:269–270.PubMedGoogle Scholar
  56. 56.
    M. Hahn-Zoric, B. Carlsson, S. Jeansson, O. Ekre, A. D. Osterhaus, D. M. Roberton, and L. Å. Hanson (1993). Anti-idiotypic antibodies to poliovirus in commercial immunoglobulin, human serum and human milk.Pediatr. Res. 33:475–480.PubMedGoogle Scholar
  57. 57.
    K. E. Stein and T. Söderström (1984). Neonatal administration of idiotype or antiidiotype primes for protection againstEscherichia coli K13 infection in mice.J. Exp. Med. 160:1001–1011.PubMedGoogle Scholar
  58. 58.
    G. P. Lucas, C. L. Cambiaso, and J. P. Vaerman (1991). Protection of rat intestine against cholera toxin challenge by monoclonal anti-idiotypic antibody immunization via enteral and parenteral route.Infect. Immun. 3651–3658.Google Scholar
  59. 59.
    R. Silfverdahl, L. Bodin, S. Hugosson, Ö. Garpenholt, B. Werner, E. Esbjörner, B. Lindquist, and P. Oleén (1995). Protective effect on breastfeeding on invasiveHeamophilus influenzae infection: a case control study in swedish preschool children. (in manuscript).Google Scholar
  60. 60.
    U. M. Saarinen and M. Kajosaari (1995). Breastfeeding as prophylaxis against atopic disease: prospective follow-up study until 17 years old.Lancet 346:1065–1069.PubMedGoogle Scholar

Copyright information

© Plenum Publishing Corporation 1996

Authors and Affiliations

  1. 1.Department of Clinical ImmunologyUniversity of GöteborgGöteborgSweden

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