European Journal of Clinical Microbiology

, Volume 6, Issue 3, pp 286–290

Serological studies in Crohn's disease

  • J. P. Ibbotson
  • P. E. Pease
  • R. N. Allan
Article

DOI: 10.1007/BF02017614

Cite this article as:
Ibbotson, J.P., Pease, P.E. & Allan, R.N. Eur. J. Clin. Microbiol. (1987) 6: 286. doi:10.1007/BF02017614

Abstract

ELISA and immunofluorescence tests were carried out on sera from patients with Crohn's disease and ulcerative colitis. The results indicate that mean antibody levels toYersinia enterocoliticatypes O∶9 and O∶3 andKlebsiella pneumoniae,but notPseudomonas maltophilia,are significantly higher in these patients than in control subjects. There are differing antibody levels in ileal and colonic disease, and there is a significant fall in antibody levels 9–12 months after remission from clinical symptoms in patients providing serial serum samples. However, there is no correlation between the severity of the disease and antibody titres.

Copyright information

© Friedr. Vieweg & Sohn Verlagsgesellschaft mbH 1987

Authors and Affiliations

  • J. P. Ibbotson
    • 1
  • P. E. Pease
    • 1
  • R. N. Allan
    • 2
  1. 1.Department of Medical MicrobiologyUniversity of BirminghamUK
  2. 2.General HospitalBirminghamUK

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