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Pharmaceutisch Weekblad

, Volume 13, Issue 6, pp 254–256 | Cite as

Compatibility of bupivacaine and iohexol in two mixtures for paediatric regional anaesthesia

  • P. Van Asten
  • J. H. Glerum
  • E. R. Spaanderman
  • J. Van Niekerk
  • A. Van Dijk
Practice/Case Reports

Abstract

The compatibility of bupivacaine (0.25% and 0.125% wt/vol) with iohexol 300 mg I/ml was investigated. At room temperature bupivacaine does not decompose in these mixtures over a period of 24 h. pH Values (7.10 and 7.33), clarity, osmolality (370 and 379 mOsm/kg) and buffer capacity (0.035 ml and 0.010 ml 0.1000 mol/l NaOH per 10 ml) meet requirements for epidural injection. Both mixtures are suitable for epidurography.

Keywords

Anesthesia, epidural Bupivacaine Drug compatibility Drug compounding Drug stability Iohexol 

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Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1991

Authors and Affiliations

  • P. Van Asten
    • 1
  • J. H. Glerum
    • 1
  • E. R. Spaanderman
    • 1
  • J. Van Niekerk
    • 2
  • A. Van Dijk
    • 1
  1. 1.Department of Hospital PharmacyUniversity Hospital UtrechtGA Utrechtthe Netherlands
  2. 2.Centre of AnaesthesiologyUniversity Hospital Utrechtthe Netherlands

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