Pediatric Radiology

, Volume 23, Issue 2, pp 91–93

Fibrodysplasia ossificans progressiva and synovial chondromatosis

  • G. Kalifa
  • C. Adamsbaum
  • C. Job-Deslande
  • J. Dubousset
Selected Papers from the 29th Congress of the European Society of Pediatric Radiology, Budapest, Hungary, 27 April–1 May, 1992

Abstract

Two cases of an unusual association — fibrodysplasia ossificans progressiva and synovial chondromatosis — in non-related children are presented. This association does not seem coincidental and raises several questions about the pathogenesis. A genetic hypothesis related to G proteins is proposed. This is supported by the fact that such abnormalities have been demonstrated in pseudohypoparathyroidism and fibrous dysplasia; these diseases can also be associated with fibrodysplasia ossificans progressiva.

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References

  1. 1.
    Cremin B, Connor JM, Beighton P (1982) The radiological spectrum of fibrodysplasia ossificans progressiva. Clin Radiol 33: 499–508PubMedGoogle Scholar
  2. 2.
    Hall CM, Sutcliffe J (1979) Fibrodysplasia ossificans progressiva. Ann Radiol (Paris) 22: 119–123Google Scholar
  3. 3.
    Thickman D, Bonakdar-Pour A, Clancy M, Van Orden J, Steel H (1982) Fibrodysplasia ossificans progressiva AJR 139: 935–941PubMedGoogle Scholar
  4. 4.
    Caron KH, Dipietro MA, Aisen AM, Heidelberger KP, Phillips WA, Martel W (1990) MR imaging of early fibrodysplasia ossificans progressiva. J Comput Assist Tomogr 14: 318–321PubMedGoogle Scholar
  5. 5.
    Malter IJ, McAlister WH (1972) Pseudohypoparathyroidism and myositis ossificans progressiva in the same patient. J Can Assoc Radiol 23: 27–32PubMedGoogle Scholar
  6. 6.
    Frame B, Azad N, Reynolds WA, Saeed SM (1972) Polyostotic fibrous dysplasia and myositis ossificans progressiva: a report of coexistence. Am J Dis Child 124: 120–122PubMedGoogle Scholar
  7. 7.
    Patten JL, Johns DR, Valle D, Eil C, Gruppuso PA, Steele G, Smallwood PM, Levine MA (1990) Mutation in the gene encoding the stimulatory G protein of adenylate cyclase in Albright's hereditary osteodystrophy. N Engl J Med 322: 1412–1419PubMedGoogle Scholar
  8. 8.
    Levine MA (1991) the McCune-Albright syndrome: the whys and wherefores of abnormal signal transduction. N Engl J Med 325: 1738–1740PubMedGoogle Scholar
  9. 9.
    Weinstein LS, Shenker A, Gejman PV, Merino MJ, Friedman E, Spiegel AM (1991) Activating mutations of the stimulatory G protein in the McCune-Albright syndrome. N Engl J Med 325: 1738–1740PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • G. Kalifa
    • 1
  • C. Adamsbaum
    • 1
  • C. Job-Deslande
    • 1
  • J. Dubousset
    • 1
  1. 1.Department of RadiologyHôpital Saint Vincent de PaulParisFrance

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