European Journal of Pediatrics

, Volume 149, Issue 6, pp 396–398 | Cite as

Influence of intrauterine growth retardation on parameters of liver function in low birth weight infants

  • G. Boehm
  • D. M. Müller
  • B. Teichmann
  • P. Krumbiegel


To establish nutritional management of low birthweight infants according to their individual metabolic situation, hepatocellular partial function was studied in 13 appropriate (AGA) and 11 small-for-gestational-age (SGA) low birthweight (LBW) infants during the first weeks of postnatal life. The concentrations of total bile acids and of alpha-amino-nitrogen in serum, the renal excretion of urea and ammonia and the renal excretion of15N after enteral administration of 3 mg15N-labeled methacetin/kg were measured. In comparison to AGA infants, SGA infants had elevated serum concentrations of total bile acids and of alpha-amino-nitrogen, decreased excretion of urea, increased excretion of ammonia in urine, and lower urinary15N-excretion after enteral administration of15N-labeled methacetin. The data suggest that hepato-cellular functions are influenced by intrauterine growth retardation resulting in a reduced metabolic capacity in SGA infants. The metabolic differences between SGA and AGA infants should be considered in the nutritional management of LBW infants.

Key words

Low birth weight infants Small-for-gestationalage Liver functions 



appropriate for gestational age


intrauterine growth retardation


low birth weight


small for gestational age


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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • G. Boehm
    • 1
  • D. M. Müller
    • 1
  • B. Teichmann
    • 1
  • P. Krumbiegel
    • 2
  1. 1.Department of PaediatricsKarl-Marx-UniversityLeipzigGerman Democratic Republic
  2. 2.Central Institute for Isotope and Radiation ResearchLeipzigGerman Democratic Republic

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