Serum calcium, phosphate and alkaline phosphatase and morphometric bone examinations in 30 patients with renal insufficiency
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Abstract
In 30 patients with chronic renal insufficiency (16 non-dialysed and 14 on dialysis) serum calcium, phosphate and alkaline phosphatase were determined and, in a crest biopsy specimen, morphometric determinations of bone qualities were calculated. A positive correlation was established between serum alkaline phosphatase, the osteoblast surface and the active resorption surface in both dialysed and non-dialysed patients. A positive correlation was also established between the osteoblast surface and the active resorption. In the non-dialysed patients a negative correlation was established between serum calcium and the osteoid surface.
Key words
Serum Calcium Phosphate Alkaline phosphatase KidneyPreview
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References
- Avioli, L. V., Birge, S., Lee, S. W., Slatopolsky, E.: The metabolism of vitamin D3-3H in chronic renal failure. J. clin. Invest.47, 2239 (1968)PubMedGoogle Scholar
- Bijvoet, O. L. M.: The assessment of phosphate reabsorption. Clin. chim. Acta26, 15 (1969)CrossRefPubMedGoogle Scholar
- Bricker, N. S., Slatopolsky, E., Reiss, E., Avioli, L. V.: Calcium, phosphorus and bone in renal disease and transplantation. Arch. intern. Med.123, 543 (1969)CrossRefPubMedGoogle Scholar
- Curtis, J. R., Wardener, H. E. de, Gower, P. E., Eastwood, J. B.: The use of calcium carbonat and phosphat without vitamin D in the management of renal osteodystrophy. In: Europ. Dialysis Transplant Ass, p. 19, J. Congress, Barcelone 1970Google Scholar
- Duursma, S. A., Visser, W. J., Njio, L.: A quantitative histological study of bone in 30 patients with renal insufficiency. Calcif. Tiss. Res.9, 216 (1972)Google Scholar
- Duursma, S. A., Visser, W. J., Zoeren, M. v., Korver, M. F.: A bone biopsy procedure. Calcif. Tiss. Res.4, 269 (1969)Google Scholar
- Fraser, D. R., Kodicek, E.: Unique biosynthesis by kidney of a biologically active vitamin D metabolite. Nature (Lond.)228, 764 (1970)CrossRefGoogle Scholar
- Garner, A., Ball, J.: Quantitative observations on mineralised and unmineralised bone in chronic renal azotaemia and intestinal malabsorption syndrome. J. Path. Bact.91, 545 (1966)CrossRefPubMedGoogle Scholar
- Harris, W. H., Heaney, R. P.: Skeletal renewal and metabolic bone disease (continued). New Engl. J. Med.280, 253 (1969)PubMedGoogle Scholar
- Kleeman, C. R., Massry, S. G., Coburn, J. W., Popovtzer, M. M.: Renal osteodystrophy, soft tissue calcification and disturbed divalent ion metabolism in chronic renal failure. Arch. intern. Med.124, 262 (1969)CrossRefPubMedGoogle Scholar
- Kuhlencordt, F., Bauditz, W., Lozano-Tonkin, C., Kruse, H. P., Augustin, H. J., Rehpenning, W., Bartelheimer, H.: Osteopathien und Calcium-Phosphat-Stoffwechsel bei chronischer Hämodialyse. Klin. Wschr.49, 134 (1971)CrossRefPubMedGoogle Scholar
- Liu, S. H., Chu, H. J.: Studies of calcium and phosphorus metabolism with special reference to pathogenesis and effects of dihydrotachysterol (A.T. 10) and iron. Medicine (Baltimore)22, 103 (1943)Google Scholar
- Merz, W. A.: Die Streckenmessung an gerichteten Strukturen im Mikroskop und ihre Anwendung zur Bestimmung von Oberflächen-Volumen-Relationen im Knochengewebe. Dissertation, Basel 1967Google Scholar
- Nguyen, V. v., Jowsey, J.: Bone metabolism. The acute effects of hormones, vitamin D3, and acidosis during in vivo perfusion of adult dog forelimbs. J. Bone Jt. Surg.52, 1041 (1970)Google Scholar
- Ogg, C. S.: The intestinal absorption of47Ca by patients in chronic renal failure. Clin. Sci.34, 467 (1968)Google Scholar
- Potts, J. T., Reitz, R. E., Deftos, L. J., Kaye, M. B., Richardson, J. A., Buckle, R. M., Aurbach, G. D.: Secondary hyperparathyroidism in chronic renal disease. Arch. intern. Med.124, 408 (1969)CrossRefPubMedGoogle Scholar
- Schäfer, K., Schäfer, P., Koeppe, P., Opitz, A., Höffler, D.: Untersuchungen zur Frage der urämische Osteopathie. Dtsch. med. Wschr.93, 1018 (1968)PubMedGoogle Scholar
- Schenk, R. K.: Zur histologischen Verarbeitung von unentkalkten Knochen. Acta anat. (Basel)60, 3 (1965)Google Scholar
- Schenk, R. K., Merz, W. A.: Histologisch-morphometrische Untersuchungen über Altersatrophie und senile Osteoporose in der Spongiosa des Beckenkammes. Dtsch. med. Wschr.94, 206 (1969)PubMedGoogle Scholar
- Stanbury, S. W.: Bone disease in uremia. Amer. J. Med.44, 714 (1968)CrossRefPubMedGoogle Scholar
- Stanbury, S. W., Lumb, G. A., Mawer, E. B.: Osteodystrophy developing spontaneously in the course of chronic renal failure. Arch. intern. Med.124, 274 (1969)CrossRefPubMedGoogle Scholar
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